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《Chinese Journal of Difficult and Complicated Cases》 2007-01
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Effect of Tongxinluo capsule on intercellular adhesion molecule-1 in patients with unstable angina pectoris

YE Da-hua,XIE Yi-qin.Longchuan County Hospital of Traditional Chinese Medicine,Guangdong,Longchuan 517300,China  
Objective To observe the effect of Tongxinluo on soluble intercellular adhesion molecule-1 (sICAM-1) in patients with unstable angina pectoris.Methods 60 cases with unstable angina pectoris were randomly divided into treatment group (n=30,routine treatment added Tongxinluo) and control group (n=30,routine treatment).Before and after 1 month's treatment,sICAM-1 in serum and blood lipids were measured.Results After treatment,the cocentrations of serum TC and LDL-C were significantly decreased in both group (P0.05),but there was no difference between two groups.The levels of TG decreased and HDL-C increased in both group,but there were no significant difference in two groups (P0.05).The level of serum sICAM-1 was decreased from (129.37±32.29)ng/ml to (78.42±26.42)ng/ml in treatment group,and decreased from (122.32±36.12)ng/ml to (89.24±21.25)ng/ml in coutrol group,and it was lower in Tongxinluo group than that in control group (P0.05).Conclusions Tongxinluo can decrease the level of serum sICAM-1 in patients with unstable angina pectoris,it suggests that Tongxinluo maybe depress vascular imflammation and protect endothelial cells.
【CateGory Index】: R259
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