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《Chinese Journal of Difficult and Complicated Cases》 2007-01
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A study on levels of serum P-selectin and homocysteine and their effects on patients with subcortical arteriosclerotic encephalopathy

YANG Hua,XIA Zhang-yong,WANG Yan-xin,et al.Department of Neurology,The Third People's Hospital of Liaocheng, Shandong,Liaocheng 252000,China  
Objective To explore the levels of serum P-selectin and homocysteine (Hcy) and their clinical effect on patients with subcortical arteriosclerotic encephalopathy (SAE).Methods 54 patients with SAE and 57 healthy elderly subjects were selected.Fasting levels of serum P-selectin and Hcy were measured with enzyme immunassay and were compared between the two groups.Results The levels of P-selectin and Hcy in the group of SAE group were significantly higher than those in the control group (P0.01 or P0.001).Serum P-selectin level was positively correlated with Hcy level (r=0.302,P0.05).Conclusion Levels of serum P-selectin and Hcy increased significantly in the patients with SAE.They may be important to early stage diagnosis and prediction of SAE.They may be take part in occurrence and development of SAE by the mechanism of causing thrombosis.
【CateGory Index】: R749.13
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