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《Chinese Journal of Difficult and Complicated Cases》 2007-01
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Study on the level of vascular endothelial growth factor in patient with leukoaraiosis

WANG Shi-jie,WANG Dao-qiang,LI Feng-lian.The People's Hospital of Juancheng,Shandong,Juancheng 274600,China  
Objective To explore the clinical significance of VEGF in patients with leukoaraiosis (LA).Methods Enzyme-linked immunosorbent assay (ELISA) was used for determination of VEGF contents in blood serum in 45 patients with LA and 20 healthy persons.The patients with LA were divided into 4 grades according to degree of leukoaraiosis,and were also divided into two groups in which one with cerebral infarction and the other without cerebral infarction.Then the contents of VEGF in different grades and groups were compared.Results The contents of VEGF in the patients with LA were significantly higher than that in control group (P0.01),except LA I group,furthermore the content of VEGF were gradually increased along with degree of leukoaraiosis (P0.01 or P 0.05).The content of VEGF in group with cerebral infarction were significantly higher than that in group without cerebral infarction (P0.01).Conclusion VEGF is related to the occurrence and development of LA.VEGF contents in blood serum indicates the degrees of LA and severity of cerebral ischemia.
【CateGory Index】: R742
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