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《Chinese Journal of Difficult and Complicated Cases》 2007-01
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Observation of combination of heparin and naloxone on the treatment of type II respiratory failure of chronic obstructive pulmonary disease

YANG Xiang-dong,CAO Zhen-fang,LI Hua.Puren Hospital of Wuhan,Hubei,Wuhan 430080,China  
Objective To observe the clinical effect of heparin and naloxone for the treatment of type II respiratory failure of chronic obstructive pulmonary disease (COPD).Methods 52 certified patients were selected and divided into two groups according to parallelism and random,treatment group and control group,26 patients in each group respectively.In treatment group heparin sodium 6 250 U to sodium chloride 250 ml and intraveneous drop,later inject once a day,7~15 days for the course of treatment;at the same time,at first inject naloxone 0.4 mg intraveneous and then add up 0.8~1.2 mg to 250 ml of sodium chloride intraveneous drop,then keep up till patient come to himself,later inject naloxone once a day,a course needs about 7~15 days.Patients in control group were treated by routine therapy.Result The treatment group was obviously shorter than the control group in the length of stay and the time of clinical relieve.There were significat difference between the two groups (P0.05).Conclusion The combination of heparin and naloxone is effective for the treatment of type II respiratory failure of COPD.
【CateGory Index】: R563.9
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