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《Chinese Journal of Difficult and Complicated Cases》 2007-01
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Effect of combination of arsenic trioxide and ginsenoside Rg3 on invasion and metastasis of human hepatocarcinoma cells SMMC-7721 in vitro

YU Gui-fang,ZENG Wen-ting,ZHU Ke-lun,et al.Institute of Hepatology,the First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China  
Objective To study the difference of arsenic trioxide (As_2O_3) or ginsenoside Rg3 alone,as well as their combination application in adhesion and invasion metastasis of SMMC-7721 human liver cancer cell in vitro.Methods MTT was used to study the effect of adhesion treated by As_2O_3 combined with ginsenoside Rg3 on SMMC-7721 cell.The Transwell Chamber membrane invasion culture system was used to study the invasion and metastasis.Results The As_2O_3 or ginsenoside Rg3 alone and their combination application could significantly inhibit SMMC-7721 cell adhesion with Matrigel,movement and migration through Matrigel than those in the control group (P 0.05).Their combination application enhanced the effect compared with As_2O_3 or ginsenoside Rg3 alone (P 0.05).Conclusion As_2O_3 or ginsesnoside Rg3 alone have the effect of antagonizing hepatocarcinoma cell adhesion and invasion metastasis,their combination application could enhance the effect.
【CateGory Index】: R735.7
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