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《Chinese Journal of Difficult and Complicated Cases》 2007-12
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Experimental study on the regulation effect of Liangxuehuoxue decoction on the related immunoregulation function of dendritic cell in peripheral blood of patients with psoriasis vulgaris

LIU Jing-sheng,YANG Li,LI Yan-jia,et al.Hebei Center for Disease Prevention and Control,Hebei,Shijiazhuang 050021,China  
Objective To investigate the intervention effect of Liangxuehuoxue decoction on dendritic cell(DC)in patients with psoriasis vulgaris in vitro.Methods The DCs in peripheral blood of patients with psoriasis vulgaris were cultured in vitro,then they were treated by Liangxuehuoxue decoction.The phenotypic changes of theses cells were detected by flow cytometry,the proliferation state induced by lymphocytes was observed by MTT method and the changes of cytokine secreted by DC were observed by ELISA.Results After DCs were treated by Liangxuehuoxue decoction,the expression of CD83 was significantly increased,however,the expression of CD86 and the stimulated ability of mixed lymphocyte proliferation was inhibited at some extent.The production of Th1 type cytokines was decreased obviously,however,the production of Th2 type cytokines was increased.Conclusion The Liangxuehuoxue decoction has certain regulation effect on the antigen presentation ability in patients with psoriasis vulgaris,and has inhibition effect on the secretion of Th1 type cells,but has promoting effect on the secretion of Th2 type cells.
【Fund】: 河北省科学技术研究与发展计划项目(No.04276101D-39)
【CateGory Index】: R275
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