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《Chinese Journal of Difficult and Complicated Cases》 2007-12
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The effect of ginsenoside Rg3 combined with arsennic trioxide on the proliferation of human hepatocellular carcinoma

HE Fang,ZENG Wen-ting,SHEN Hao-xian.Morphology Experiment Center,Guangzhou Medical Collage,Guangdong,Guangzhou 510182,China  
Objective To observe the therapeutic effect of ginsenoside Rg3 combined with arsennic trioxide(As2O3)on transplanted hepatic carcinoma in nude mice and to investigate its effect on the proliferation of hepatoma cells of transplanted carcinoma.Methods 32 male nude mice were randomly divided into 8 groups,and transplanted hepatic carcinoma models were set up by subcutaneously implanting human hepatic carcinoma cell strain(Bel-7402).The mice in treatment groups were treated by Rg3(5 mg/kg,10 mg/kg,20 mg/kg)combined with As2O3,Rg3(5 mg/kg,10 mg/kg,20 mg/kg)alone,As2O3(40 μg·kg-1·d-1)alone and saline(0.5 ml,qd)respectively.3 days after the nude mice were inoculated,Rg3 was given by gastrogavage once every 2 days for 20 times,As2O3 was injected introperitoneally once a day for 28 days.A week after treatment being stopped,the mice were killed and the size of solid tumors was measured,tumor inhibition rate was calculated and intratumor PCNA was detected by immunohistochemical staining.Results The tumor inhibition rate(55.25%)in As2O3 group was higher than that(32.24%,45.10%,50.00% respectively)in Rg3 subgroups,but with the increase of dosage,the difference was not obvious.Among combined drug groups,in 5 mg/kg subgroup tumor mean weight was(0.58±0.15)g and tumor inhibition rate was 61.84%;in 10 mg/kg subgroup mean tumor weight was(0.54±0.11)g and tumor inhibition rate was 64.47%;in 20 mg/kg subgroup mean tumor weight was(0.49±0.12)g and inhibition tumor rate was 67.76%,that was significantly higher than that of As2O3 group(P0.05).The inhibiting effect on the proliferation of hepatoma cells in As2O3 group(PI:38.3±5.3)was superior to that of Rg3 group(PI:58.1±2.4,51.8±5.3,41.9±6.5 respectively).The effects in combined drug group(PI:38.6±8.4,30.9±3.2,23.3±3.3 respectively)were greatest,which could obviously inhibit the proliferation of hepatoma cells of transplanted tumor.Conclusion As2O3 can inhibit the growth of transplanted human hepatic carcinoma in nude mice mainly through inhibiting the expression of PCNA.Rg3 combined with As2O3 has synergistic effect in inhibiting the proliferation of hepatoma cells of transplanted tumor.
【CateGory Index】: R735.7
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