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《Chinese Journal of Difficult and Complicated Cases》 2008-01
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Meta analysis for a randomized and controlled trial of the therapeuticeffect of human b type natriuretic peptide on chronic congestive heart failure

CHEN Ke-qi LIAO Bi-hong Department of Cardiology,Shenzhen People' s Hospital/The Second Medical College of Jinan University,Guangdong,Shenzhen 518020,China  
Objective To investigate the effect of human b-type natriuretic peptide(BNP)on hemodynamics in treating patients with chronic congestive heart failure(CHF)and its safety and tolerance.Methods Using CHF as subjective words and BNP and Nesiritide as test words respectively,to search and select the data in MEDLINE Data- base and to conduct randomized controlledtrials(RCT).Results A total of 13 clinical RCT were included.Their in- clusions,methodology and rresults were evaluated.Nesiritide could decrease pulmonarycapillary wedge pressure(PC- WP)by average 4.06 mmHg,95% CI[-4.79,-3.33,(P0.01)],and which could increase cardiac index (CI)by 0.08 L·min~(-1)·m~2,95% CI[0.02,0.15,(P=0.01)],and could decrease heart rate and improve the pa- rameters of hemorrheology and ECG.For the patients with high risk,Nesiritide could decrease mortality causedby dif- ferent reasons.Conclusion BNP can effectively improve hemedynamicsin patients with CHF,and can reduce long- term mortality in patients with severe CHF.The treatment doses are safe and tolerant,so a low-dose BNP is recom- mended to be used in clinic.
【CateGory Index】: R541.6
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1 LI Jie. Department of Internal Medicine,The Port Hospital of Tianjin,Tianjin 300450,China;Effect of hemoglobin concentration on the prognosis of patients with chronic heart failure[J];Hebei Medical Journal;2009-09
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