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《Chinese Journal of Difficult and Complicated Cases》 2008-01
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Effects of tirofiban on ventricular remodeling and cardiac function after myocardial ischemia/reperfusion in rats

LIU Ling-mei~* LIU Yan-hong ZHANG Mei ~*Haihe Hospital,Tianjin 300350,China.  
Objective To investigate effects of tirofiban on ventricular remodeling and cardiac function after myocardial ischemia/reperfusion in rats.Methods 36 male Wistar rats were randomized into three groups,sham op- eration group,model control group and tirofiban treatment group(12 rats in each group).The animal models of myo- cardial ischemia/reperfusion were established.The rats in control group and tirofiban group were subjected ischemia for 90 minutes by ligation of coronary artery after thoracotomy and sequent persistent reperfusion.While the rats in sham operation group didn't underwent occlusion of coronary artery.On the 28th day after operation,hemodynamic parame- ters and cardiac function in all survival rats were evaluated.The rats were killed.Picrosirius red staining plus light mi- croscopy was used to analyze quantitatively the thickness of left ventricular free wall(LVWT)in infracted region(left ventricular free wall for sham group),septum(SPT)and ratio of SPT/LVWT,myocardial across area in septum(MAAS) and collagen volume fraction(CVF)in non-infarcted and infracted region(left ventricular free wall for sham group). Results The hemodynamics analysis showed SBP,DBP,LVSP,±dp/dt_(max)in model control group and tirofiban treat- went group were significantly lower than those of sham operation group,however,LVEDP was obviously higher than that of sham operation group(P0.01 or P0.05).The±dp/dt_(max)in tirofiban treatment group was significantly higher than that of model control group(P0.05),but LVEDP was lower than that of model control group(P0.05).Although SBP,DBP,LVSP in tirofiban treatment group were higher than those of model control group,there were no significant differences hotween two groups(P0.05).After 28-day ischemia/reperfusion,LVMT in in model control group and tirofiban treatment group was significantly lower than that of sham operation group(P0.01), however,SPT/LVMT,MAAS,CVF in infracted region were obviously higher than those of sham operation group(P0.01),but there were no significant differences in SPT and CVF 3 in non-infracted region among three,groups(P0.05).The LVMT in tirofiban treatment was obviously higher than that of model control group(P0.05),while SPT/LVMT,MAAS,CVF were obviously lower than those of model control group(P0.01).Conclusion Tirofiban can inhibit ventricular remodeling after myocardial ischemia/reperfusion in rats and improve cardiac function.
【CateGory Index】: R542.22
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