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《Chinese Journal of Difficult and Complicated Cases》 2008-01
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The effect of trimetazidine on cTnI, CRP, LVEF of patients received 4'epi-doxorubicin

LIU Ya-lin FU Hua MA Jing-tao Department of Cardiology,The Fouth Hospital of Hebei Medical University,Hebei,Shijiazhuang 050011,China  
Objective To investigate the protective effect of trimetazidine(TMZ)on myocardium in patients received 4'epi-dnxorubicin(EPI).Methods 42 patients whose myocardium were damaged because of the administra- tion of EPI were randomly divided into two groups.21 patients in treatment group received TMZ,Lhe other 21 patients were in control group.After 1-month the changes of cardiac troponin I(cTnI),C-reactive protein(CRP)and left ven- tricle ejective fraction(LVEF)were observed and compared between two groups.Results After treatment the levels of cTnI in treatment group and control group were[(0.57±0.07)mg/L vs(1.12±0.08)mg/L],the levels of CRP were [(4.9±1.2)mg/L vs(8.8±4.2)mg/L]respectively,there were significantly decreases in these parameters between two groups(P0.05).At the same time,patients' cardiac systolic function was improved[LVEF,(52±3)% vs (41±2)%],there was significant differences bet ween the two groups(P0.05).Conclusion TMZ can improve cardiac function anti reduce the serum levels of cTnI and CRP in patients received EPI.
【CateGory Index】: R96
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