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《Chinese Journal of Difficult and Complicated Cases》 2008-01
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The molecular biological action mechanism of Jieduhuazhuohewei decoction in blocking chronic atrophic gastriffs and precancerous lesions in rats

ZHAO Yu-bin~* XIAO Ying LI Dian-gui ~*Department of Digestive Disease,The Third Hospital of Shijiazhuang,Hebei,Shijiazhuang 050011,China  
Objective To investigate molecular biological action mechanism of Jieduhuazhuohewei decoction in blocking chronic atrophic gastritis(CAG)and precancerous lesions of gastric cancer(PLGC).Methods 60 Wistar rats were divided randomly into 4 groups:blank control group,model control group,TCM group,western drug group,15 rats in each group.Besides blank control group,the rats in other 3 groups were treated with MNNG to estab- lish the models.The rats in model control group were given double distilled water by gavage,the rats in TCM group were given Jieduhuazhuohewei decoction by gavage,while the rats in western drug group were given folacin by garage. The concentrations of EGFR were measured in all the groups.The expressions of EGFR were measured by RT-PCR. Proliferative cell nucleus antigen(PCNA),apoptosis index,change of expression of H-ras in slices of precancerous morbid tissues of gastric mucosa were measured after application of these drugs.Results The concentration of EGFR of TCM group and western drug group were significantly lower than those of model control group(P0.05),the ex- pression of EGFR in TCM group was obviously lower than that of model control group.The expressions of PCNA and H- ras in TCM group decreased remarkably,which were significantly different from those of other groups(P0.01 or P0.05).Conclusion Jieduhuazhuobewei decoction has blocking effect on the proliferation of PLGC cells of rats. which may related with the down-regulation of the expression of EGFR and mRNA of PLGC tissues.
【Fund】: 河北省科技攻关计划项目(06276102D-115)
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 2 Hits
1 Lan Chunhui, Wu Xiaoling (Department of Castroenterology, the Daping Hospital of the Third Military Medical University,Chongqing;Expression of Epidermal Growth Factor and its Receptor in Gastric Carcinoma and Precancerous Lesions[J];CHONGQING MEDICAL JOURNAL;2000-03
2 ZHANG Hong,XU Lei (Fujian Tumor Hospital,Fuzhou 350014,China);The Expression of EGFR in Gastric Carcinoma and Precancerous Lesion and its Clinical Significance[J];Zhejiang Cancer Journal;2001-04
Chinese Journal Full-text Database 9 Hits
1 ;Influences of Yangzheng Sanjie Decoction on EGF,EGFR of Gastric Mucosa at Precancerosis of Chronic Atrophic Gastritis[J];Guiding Journal of TCM;2007-12
2 TANG Xu-dong, BIAN li-qun,WANG Ping.Gastoreaterology Internal Department,Xiyuan Hospital,China Academy of Traditional Chinese Medicine,Beijing 100091,China;New development in the prevention and treatment of gastrointestinal disease by TCM[J];Global Traditional Chinese Medicine;2009-04
3 HUANG Miao\|zhen (Medical College of Hangzhou Teachers College, Hangzhou, Zhejiang, 310012, China);The relative study between chronic atrophic gastritis and expressions of epidermal growth factor and somatostain[J];Journal of Hangzhou Medical College;2003-05
4 YANG Hong,ZHANG Zhong(Department of Oncology,Inner Mongolia Autonomous Region Hospital,Huhhot 010017 China);The Expression of β-cat and EGFR and Its Biological Significance in Gastric Cancer[J];Inner Mongolia Medical Journal;2008-10
5 ZHOU Jing,GAO Cheng,WU Shen-tao(Tianjin Medical University No.1 Affiliated Hospital,Tianjin,300193,China);Pathogenic Mechanism of toxic cloud[J];Journal of Traditional Chinese Medicine University of Hunan;2009-12
6 YANG You-xin1 YUAN Hong-xia1 DAI Er-qing2 ZHAO Qiang3 MA Yan1 1.International School,Tianjin University of Traditional Chinese Medicine 2.Affiliated Hospital of Arm Force Medical College,Tianjin 3.First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine;Correlativity Between Chinese Medical Syndromes of Precancerous Lesion of Chronic Atrophic Gastritis and EGF,EGFR and TGF-α Expressions[J];Shanghai Journal of Traditional Chinese Medicine;2008-07
7 LI Dian-gui, ZHAO Yu-bin, GU Jie,LI Gang (Hebei University,Baoding,Hebei,071000,China; Hebei Medical University, Shijiazhuang, Heibei,050011,China);Molecular Bilolgical Mechanism of Jiedu Huazhuo Hewei Remedy on Blocking Precancerous Lesions of Chronic Atrophic Gastritis in rats[J];World Journal of Integrated Traditional and Western Medicine;2006-01
8 Yun-Lian Hu, Digestive internal Department, Hubei Provincial Traditional Chinese Medicine Hospital, Wuhan 430061, Hubei Province, China Jiang Nan, Da-Qi Tan, Focus Lab, Hubei Provincial TCM Hospital, Wuhan 430061, Hubei Province, China;Effect of Jiawei Zuojin Wan on expression of epidermal growth factor receptor, vascular endothelial growth factor, C-met, Bcl-2 and P53 protein in rats with gastric precancerous lesions[J];World Chinese Journal of Digestology;2006-07
9 JIANG Li.(Department of Endoscopy,Tanggu District Hospital of Traditional Chinese Medicine,Tinjin 300451,China);Rcent Development in Cognition and Treatment of Chronic Gastritis by Traditional Chinese Medicine[J];Medical Recapitulate;2008-22
Chinese Journal Full-text Database 10 Hits
1 Dong Jianhua et al.(Affiliated Hospital of Beijing College of TCM, Beijing);Observation of Stuffy Sensation of Deficiency Type (Precancerous CAG) Treated by TCM[J];;1989-06
2 Li Qiujuan,Zhong Laifu,Ye Jianxin,et al Department of Hygiene,Dalian Medical University;Studies on the relation of chronic atrophic gastritis to gastric mucosa somatostain and gastrin in rats[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;1999-02
3 LI Xiao Bin 1, XIA Tian 1, ZHANG Zhong Hai 1, WANG Zong Ren 1, WANG Wen 1, LIU Guo Cheng 2, ZHANG Bi Cheng 3, YANG Guo Yu 4 1Department of Traditional Chinese Medicine, 2Department of Nuclear Medicine, Xijing Hospital, 3De;Xiaoweilin acts on gastric mucosa blood flow and plasma motilin level in rats with atrophic chronic gastritis[J];Journal of The Fourth Military Medical University;2002-09
4 YAO Yong-li1, XU Bo2, SONG Yu-gang1, ZHI Fa-chao1, ZHANG Wan-dai1 (1Institute of Digestive Disease of PLA, 2Department of Orthopaedics, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China);Motilin and gastrointestinal disturbance: an experimental study[J];Journal of First Military Medical University;2001-08
5 Wang Dejun,Sun Yun,Deng Yangmei,et al. Medical College University Yangzhou,Yangzhou 225001 China;Histiopathology study of Yang Wei Granule on gastric mucosa of chronic atrophic gastritis in rat[J];Anatomy Research;2001-04
6 LI Diangui, BAI Yaping, LU Jincang, et al. Hebei Workers Medical College, Baoding 071000;Clinical study of functional dyspepsia treated by a method of Huazhuojiangni[J];Hebei Journal of Traditional Chinese Medicine;2004-02
7 WANG Gang,DONG Mei,GUO Huican,et al.Department of Pharmacy Engineering,Chemical Pharmaceutical Vocational Technology College,Hebei,Shijiazhuang 050031;Experimental research on Herba Scutellariae Darbatae extract of its antineoplastic activity in vitro[J];Hebei Journal of Traditional Chinese Medicine;2006-09
8 LIU Qiquan,SUN Shihua,DU Yanru,et al.Digestion Internal Department,Hebei Provincial Hospital of TCM, Hebei,Shijiazhuang 050011;Effect of recipe for deintoxication promoting blood flow on immunoglobulin in patients with precancerous lesion[J];Hebei Journal of Traditional Chinese Medicine;2007-03
9 ZHANG Hong jie, ZHAO Zhi quan, WANG Ying (Department of Gastroenterology,The First Affiliated Hospital to Nanjing Medical University,Jiangsu Nanjing 210029, China)$$$$;The Relationship between Expression of bcl-2、Bax and Gastric Cancer[J];Hebei Medicine;2001-10
10 XIA Ronglong 1), ZHENG Landong 1), LIU Qingguang 2), PAN Cheng' en 2) 1)Department of General Surgery, the First Affiliated Hospital,Henan University,Kaifeng 475001 2)Department of General Surgery, the First Affiliated Hospital,Xi'an Traffic University,Xi'an 710061;Effects of Danshen on the development of hepatocellular carcinoma in rats with malignant biliary obstruction[J];Journal of Zhengzhou University(Science Medical);2005-01
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
2 Chang Hong; Wang Zhenhua; Yan Qinghan; et al(Department of Pathology, Beijing General Railway Hospital , Beijing 100038);Expression of epidermal growth factor receptor in early gastric carcinoma[J];CHINESE JOURNAL OF DIAGNOSTIC PATHOLOGY;1996-01
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