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《Chinese Journal of Difficult and Complicated Cases》 2008-01
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The molecular biological action mechanism of Jieduhuazhuohewei decoction in blocking chronic atrophic gastriffs and precancerous lesions in rats

ZHAO Yu-bin~* XIAO Ying LI Dian-gui ~*Department of Digestive Disease,The Third Hospital of Shijiazhuang,Hebei,Shijiazhuang 050011,China  
Objective To investigate molecular biological action mechanism of Jieduhuazhuohewei decoction in blocking chronic atrophic gastritis(CAG)and precancerous lesions of gastric cancer(PLGC).Methods 60 Wistar rats were divided randomly into 4 groups:blank control group,model control group,TCM group,western drug group,15 rats in each group.Besides blank control group,the rats in other 3 groups were treated with MNNG to estab- lish the models.The rats in model control group were given double distilled water by gavage,the rats in TCM group were given Jieduhuazhuohewei decoction by gavage,while the rats in western drug group were given folacin by garage. The concentrations of EGFR were measured in all the groups.The expressions of EGFR were measured by RT-PCR. Proliferative cell nucleus antigen(PCNA),apoptosis index,change of expression of H-ras in slices of precancerous morbid tissues of gastric mucosa were measured after application of these drugs.Results The concentration of EGFR of TCM group and western drug group were significantly lower than those of model control group(P0.05),the ex- pression of EGFR in TCM group was obviously lower than that of model control group.The expressions of PCNA and H- ras in TCM group decreased remarkably,which were significantly different from those of other groups(P0.01 or P0.05).Conclusion Jieduhuazhuobewei decoction has blocking effect on the proliferation of PLGC cells of rats. which may related with the down-regulation of the expression of EGFR and mRNA of PLGC tissues.
【Fund】: 河北省科技攻关计划项目(06276102D-115)
【CateGory Index】: R285.5
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