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《Chinese Journal of Difficult and Complicated Cases》 2008-09
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The relationship between lymph node metastasis and expression of VEGF-C and its receptor in colorectal carcinoma

WANG Zhi-bo,ZHANG Yan-rong,LI Meng,et al.Department of General Surgical,the Second Affiliated Hospital of Hebei Medical University,Hebei,Shijiazhuang 050000,China  
Objective To explore the correlation between lymph node metastasis and expression of VEGF-C and its receptor(KDR)in colorectal carcinoma.Methods Retrospectively 74 specimen of colorectal carcinoma,36 of them were identified with lymph node metastasis and 38 of them without.The expression of VEGF-C and KDR was examined by immunohistochemistry in primary mass and metastatic lymph node.Results There was no statistical difference of VEGF-C expression between primary carcinoma and metastatic lymph nodes in metastasis cases(P0.05),while there was statistical difference in non-metastasis cases(P0.01).The similar results could be found in expression of KDR.Conclusion The increase of VEGF-C expression had closely relationship with genic mutation than micro-environment,the size of carcinoma and the density of carcinoma.The expression of VEGF-C and KDR were relatively with lymphatic metastasis in colorectal carcinoma.
【CateGory Index】: R735.3
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