Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2009-01
Add to Favorite Get Latest Update

The effectiveness of perindopril on the expression of angiotensin converting enzyme 2 in diabetic rats kidney

HE Chun-ling,XING Wen,WANG An-cai.Department of Endocrinology,Yijishan Hospital of Wannan Medical College,Anhui,China 241001  
Objective To research the expression of angiotensin converting enzyme 2(ACE 2)in diabetic mellitus(DM) rats and the effectiveness of perindopril.Methods Ten Wistar rats were defined as control group with normal diet,and the other 30 rats were induced diabetic model with high sucrose and high fat diet, combined STZ. Then DM rats were randomly assigned as follows:(DM)group(n=10);DM+high dose perindopril group(n=10);DM+low dose perindopril group(n=10). After 12 weeks administration. The expression of ACE 2 in kidney was determined by immunohistochemistry method. Plasma Ang II was measured with radioimmunoassay. The kidney index(KI) was calculated and compared.Results The expression of ACE 2 was lower in DM rats than control group (P0.05).The expression of ACE 2 was found to be significantly increased in perindopril group compared with those of the DM group (P0.01).Additional,the Ang II,blood sugar,and KI were decreased after administration of perindopril (P0.01 or P0.05).Conclusion It suggested that perindopril could have protective effects on diabetic nephropathy.
【CateGory Index】: R587.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 WU Qi- zhi,ZHANG Min,WONG Chao-hang,et al.Department of Internal Medicine,Huli Branch Affiliated Zhongshan Hospital of Xiamen University,Fujian,Xiamen 361006,China;The effects of irbesartan and enalapril on the renal function in patients with essential hypertension[J];Chinese Journal of Difficult and Complicated Cases;2010-01
2 YUAN Bo~*,HE Hong-yan,WANG Ming-yong,et al.* Department of Nephrosis,Yibin First People' s Hospital, Sichuan Province,Yibin 644000,China;Influence of angiotensin-(1-7) on expression of E-cadherin andα-SMA induced by angiotensinⅡin rats tubular epithelial cells[J];Chinese Journal of Difficult and Complicated Cases;2011-05
Chinese Journal Full-text Database 3 Hits
1 ZHENG Qi, JIN Xue-qing, WENG Zhi-yuan, WANG Hua-jun, XU Chang-sheng, WU Ke-gui. The first Affiliated Hospital of Fujian Medical University Hypertension Institute, Fujian Fuzhou 350005, China;The Effects of Benazepril and Valsartan on the Expression of Angiotensin Converting Enzyme2 in Kidney of Diabetic Rats[J];Chinese Journal of Hypertension;2007-06
2 *ZHOU Ying-sheng, GAO Yan, LI Bin, LIU Dong-ge, CHI Jia-min, WANG Shu, LI Jian(Department of Endocrinology, Beijing hospital, Beijing 100730, China);A Rat Model of Type 2 Diabetes Mellitus Induced by High Fat Chow and Low Dose Streptozotocin Injection[J];Acta Laboratorium Animalis Scientia Sinica;2005-03
3 TIAN Jing-lun,ZHOU Mao-ji,HE Shu-jing,et al. Department of Endocrinology,Wenjiang Peoples Hospital of Chengdu City.Sichuan Chengdu 611130,China;Effects of dyslipidemia on early insulin secretion in patients with type 2 diabetes mellitus[J];Chinese Journal of Diabetes;2008-07
Chinese Journal Full-text Database 10 Hits
1 LIU Xia1,JIN Qi-guan1,YE Ming2(1.Physical Education College,Yangzhou University,Yangzhou 225009,Jiangsu China;2.Department of sport physiology,Capital institute of physical education,Beijing 100088,China);Effects of Aerobic Exercise and Dietary Control on the Affinity of Insulin Receptor of Skeletal Muscles in Diabetic Rats[J];Journal of Beijing Sport University;2010-02
2 WU Shen-tao1,YAN Dong-xue2(1The First Teaching Hospital of Tianjin University of TCM,Tianjin 300193,China; 2Nankai Hospital of Tianjin,Tianjin 300100,China);Discussing the prevention and treatment of diabetes associated with abnormal lipid metabolism from turbidity-toxin[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-08
3 WU Yan,HAN Jing,HUANG Li-ming,GUO Shu-zhen,WANG Wei(Beijing University of Chinese Medicine,Beijing 100029,China);Research on characteristic and syndrome dynamic succession of type-2 diabetic rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-11
4 Jin Miaomiao,Mu Yiming,Niu Xiaohong HeJi Hospital Affiliated to Changzhi Medical College;The Establishment of Diabetic Rat Model Induced by Low Dose STZ and High Fat Diet and the Analysis of its Metablic Feature[J];Journal of Changzhi Medical College;2012-03
5 Fang Jing-hui Xiang Hong-ding(Diabetes Center of peking Union Medical College Hospital,Beijing,100730 China);Correlation Study of Lipoid Metabolism Change and Diabetes Cascade Develop[J];Chinese Journal of Medicinal Guide;2008-06
6 WU Qi-nan,XIAO Qian,WU Ping,LI Long-ying,GAO Yuan (Department of Gerontology,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);Effect of trimetazidine against the apoptosis of type 2 diabetic rat cardiomyocytes[J];Acta Academiae Medicinae Militaris Tertiae;2007-19
7 XING Wen,ZHANG Lin-ye,WANG An-cai.Department of Cardiology,Yijishan Hospital of Wannan Medical College, Wuhu 241000,China;Effect of perindopril on the expression of angiotensin-converting enzyme 2 in kidney of renal hypertensive rats[J];International Journal of Internal Medicine;2008-06
8 Fan Ruiming, Yu Changyin, Yang Li, et al. Department of Neurology, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003;Expression of NF-κBp65 and the Clinical Significance in Diabetic Rats model with Cerebral Ischemic Reperfusion[J];Guizhou Medical Journal;2006-11
9 FENG Jian-hua1,LI Jie2,WANG Dian-yun2,ZHANG Meng2,LIU Yuan1,LI Guo-xia1(1The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,China;2Shandong University of Traditional Chinese Medicine,Jinan 250355,China);Regulating effect of Qingrejiedufang on the signal pathway of NF-κB/IκB mRNA in the Pancreatic β cells and skeletal muscle cells of type 2 diabetic rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2013-01
10 ZHANG Fan,LENG Qin,LEI Jian,HE Liqun Dept.of Cardiology,The First Hospital of Wuhan,Wuhan 430022,China;Effects of Trimetazidine on Cardiac Fibrosis in Rats with Experimental Diabetic Cardiomyopathy[J];Medical Journal of Wuhan University;2012-03
China Proceedings of conference Full-text Database 1 Hits
1 LI Hai-yan,LI Jia-min,LI Jing-xiao,WANG Xin-xing,DAI Jie-jie, (Institute of Medical Biology,Chinese Academy of Medical Science /Peking Union Medical College, Kunming 650118,China;);Insulin-Resistance Tree Shrew Model Induced by High-glucose-fat-diet add Dexamethasone[A];[C];2010
Chinese Journal Full-text Database 6 Hits
1 LI Huihui.Department of Endocrinology,Beijing Shijitan Hospital,Beijing 100038,Bejiing;Effect of perindopril on early renal function in diabetes mellitus patients[J];Clinical Medicine;2008-03
2 ZHAO Yong-jun,HUO Meng,ZHANG Gang.Department of Cardiology,Hebei Province Geriatric Hospital,Shijiazhuang 050011,China;Impact of Perindopril on Vasodilation Function in Elderly Patients with Metabolic Syndrome and Hypertension[J];Chinese General Practice;2007-04
3 YANG Fu-yan,SHAO Feng-jie.Department of Nephropathy,the First People's Hospital of Xinxiang,Xinxiang 453000,China;Dual Blockage of Renin-Angiotensin System in Patients with Early Diabetic Nephropathy:A Study of Randomized Control Trial[J];Chinese General Practice;2008-02
4 LI Jun,CAO Xiao-xia,WANG Jun-yuan,et al.Department of Cardiology,The Second People's Hospital of Wuhu,Wuhu 241000,China;The effect of angiotensin-(1-7) on vascular function after carotid artery adventitia removal in spontaneously hypertensive rats[J];Chinese Journal of Difficult and Complicated Cases;2008-11
5 Long CHEN Bi-cheng LIU~2 Xiao-liang ZHANG Jian-dong ZHANG Hong LIU Min-xia LI Institute of Nephrology,Zhong Da Hospital,Southeast University School of Medicine,Nanjing 210009,China;Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells[J];中国药理学报(英文版);2006-08
6 WANG Hai-ying*, CAI Rong, LIU Wen-bin, GE Jun, WANG Bao-zhen, SHI Jing-heng,SHI Hong-li.*Department of Endocrinology, Kongjiang Hospital, Yangpu District, Shanghai 200093, China;An analysis for related factors influencing urinary ratio of albumin to creatinine in patients with type-2 diabetics[J];Chinese Journal of General Practitioners;2005-01
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 YANG Shi-xian,WU Tie-yong,LIU Xiao-gang.Taiyanggong Community Health Service Center of Chaoyang District,Beijing 100028,China;Expression and Significance of Claudin-7,Claudin-18 and E-cadherin in Gastric Adenocarcinoma[J];Chinese General Practice;2013-03
2 WANG Jun-yuan,WANG An-cai,CAO Heng,et al.Department of Cardiology,Affiliated Yijishan Hospital,Wannan Medical College,Anhui Province Wuhu, 241001,China;Effect of angiotensin(1-7) on myocardial remodeling in pressure loaded hypertensive rats[J];Chinese Journal of Difficult and Complicated Cases;2012-11
3 DUAN Ban-yan;DANG Shu-yi;ZHOU Ming;Department of Cardiology,Taihe Hospital,Affiliated of Hubei University of Medicine;;Comparison of irbesartan and enalapril for treating patients with acute myocardial infarction[J];Chinese Journal of Difficult and Complicated Cases;2013-11
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 LIU Hong, YANG Hui (Dept of Pharmacy, Yantaishan Hospital, Yantai 264000);Renin-angiotensin system and diabetic nephropathy[J];Anhui Medical and Pharmaceutical Journal;2003-02
2 LIU Cui-Qing 1,2 , HUANG Yu 1,3 , LU Li-Min1 (1Department of Physiology & Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032,China;2Department of Physiology, Hangzhou Normal College, Hangzhou 310018, China; 3Department of Physiology, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China);Effects of ACE2-Ang 1-7-Mas Axis on Blood Vessel[J];Progress in Physiological Sciences;2007-01
3 WENG Zhi-yuan, JIN Xue-qing, WU Ke-gui, XU Chang-sheng, WANG Hua-jun. Department of Cardiovascalar of the first aftiliated Hospital of Fujian Medical University, Institute of Hypertension of Fujian, Fuzhou 350005, China;Effects of Benazepril and Valsartan on ACE2 Expression in Kidney of SHR[J];;2006-05
4 ZHANG Fanglin, LI Guo, LIU Youping, DING Wei, YIN Jun, XU Guangwu, ZHANG Di, ZHOU Wenzhong, LUO Min (Shanghai Institute of Endrocrinology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China);Rat Model of Type 2 Diabetic Mellitus and Its Glycometabolism Characters[J];Acta Laboratorium Animalis Scientia Sinica;2002-01
5 YANG Jia-lin, LI Guo, LIOU You-pin, ZHANG Fang-lin, CUI Jiu-lan, ZHANG Di, ZHOU Wen-zhong, LUO Min (Ruijin Hospital, Shanghai Second Medical University and Shanghai Institute of Endocrinology, Shanghai 200025,China);Establishing a Rat Model Similar to the Adult Patient of the General Type 2 Diabetes by Long-Term Fat-Enriched Fed and Lower Dose of Streptozocin-Treated Rats[J];Acta Laboratorium Animalis Scientia Sinica;2003-03
6 GUO Xiaohua, LIU Zhihong, LI Heng, et al. Nanjing Univisity School of Medicine, Jinling Hospital, Research Institute of Nephrology, Nanjing 210002, China;Type 2 diabetes mellitus induced by diets and its features of renal involvement in rat[J];Chinese Journal of Diabetes;2002-05
7 LI Ping, LI Ling,LIU Cong, et al. Department of Endocrinology, The Second Hospital, China Medical University, Shenyang 110004, China;Evaluating the simple indices of insulin resistance with hyperinsulin-euglycemic clamp[J];Chinese Journal of Diabetes;2007-12
8 DU Jian 1, ZHAO YU yan 1, XIE Hui 2, ZHAO Jin (1 Department of Endocrinology, The First Clinical College, China Medical University, Shenyang 110001, China; 2 Department of Endocrinology, Shenyang Red Cross Hospital);Establishment and Evaluation of Animal Model of Insulin Resistance With High-Fatty Diet[J];Journal of China Medical University;2002-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved