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《Chinese Journal of Difficult and Complicated Cases》 2009-01
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The effectiveness of perindopril on the expression of angiotensin converting enzyme 2 in diabetic rats kidney

HE Chun-ling,XING Wen,WANG An-cai.Department of Endocrinology,Yijishan Hospital of Wannan Medical College,Anhui,China 241001  
Objective To research the expression of angiotensin converting enzyme 2(ACE 2)in diabetic mellitus(DM) rats and the effectiveness of perindopril.Methods Ten Wistar rats were defined as control group with normal diet,and the other 30 rats were induced diabetic model with high sucrose and high fat diet, combined STZ. Then DM rats were randomly assigned as follows:(DM)group(n=10);DM+high dose perindopril group(n=10);DM+low dose perindopril group(n=10). After 12 weeks administration. The expression of ACE 2 in kidney was determined by immunohistochemistry method. Plasma Ang II was measured with radioimmunoassay. The kidney index(KI) was calculated and compared.Results The expression of ACE 2 was lower in DM rats than control group (P0.05).The expression of ACE 2 was found to be significantly increased in perindopril group compared with those of the DM group (P0.01).Additional,the Ang II,blood sugar,and KI were decreased after administration of perindopril (P0.01 or P0.05).Conclusion It suggested that perindopril could have protective effects on diabetic nephropathy.
【CateGory Index】: R587.1
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