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《Chinese Journal of Difficult and Complicated Cases》 2009-07
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Influences of angiotensin II receptor antagonists on renal expression of vascular endothelial growth factor in type 2 diabetic rats

ZHANG Yu-na,XU Cai-mian,SU Guo-ying,et al.Department of Endocrine,The Fourth Hospital of Hebei Medical University,Hebei,Shijiazhuang 050011,China  
Objective To investigate the influences of angiotensin II receptor antagonists on renal expression of VEGF in type 2 diabetic rats.Methods Type 2 diabetes model was induced by long-term high-fat feeding accompanied with intraperitoneal injection of streptozotocin (STZ). The morphological changes of kidney tissue were detected by light and electron microscopy. Glomerular VEGF protein synthesis were evaluated by immunohistochemical staining.Results The main features of the diabetic renal parenchyma were observed in type 2 diabetic rats and VEGF protein was higher in type 2 diabetic rats than in control rats (P0.01).The expression of VEGF protein was decreased after treatment with irbesartan (P0.01),while the renal damage was significantly improved.Conclusion The down regulation of expression of VEGF induced by angiotensin II receptor antagonists treatment might be related to progress of diabetic nephropathy.
【Fund】: 河北省卫生厅科研基金项目(No.06176)
【CateGory Index】: R587.2
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Chinese Journal Full-text Database 1 Hits
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【Co-references】
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