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《Chinese Journal of Difficult and Complicated Cases》 2009-07
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The significance of renal cortex microcirculation alteration in obstructive jaundice rats

QIN Qi-yu,LI Yong,ZHANG Qing-fu,et al.Department of the Genneral Surgery,The First Hospital of Hebei Medical University,Shijiazhuang 050031,China  
Objective To observe the alteration and significance of renal cortex microcirculation in obstructive jaundice rats.Methods 48 SD rats were randomly divided into two groups:sham operation group(SO),common bile duct ligation group(BDL),which were observed at 3,7,10 days respectively. The characteristics of renal cortex microcirculation were studied by the WX-9 microscope for caliber,density and effusion of the capillary,and by LISCA laser Doppler hemoperfusion image instrument for the alteration of the renal cortex hemoperfusion,in different group.Results After common bile duct was ligated,the caliber of capillary contracted,and the number of hemoperfusion was decreased.At the 7th and 10th day,the amount of capillary was decreased.They were decreased more significantly along with the time (P0.05,P0.01).While there was no significant changes observed in SO group.Conclusion Obstructive jaundice can induce the microcirculation disturbance and less hemoperfusion of renal cortex in rats.
【Fund】: 河北省科技支撑计划项目(No.072761964)
【CateGory Index】: R575
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