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《Chinese Journal of Difficult and Complicated Cases》 2009-07
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The histopathological changes of non-small cell lung cancer treated with paclitaxel liposome injection as primarily chemotherapy

SHI Jian,SHAN Bao-en,WANG Xiao-ling,et al.Department of Oncology,the Fourth Hospital Affiliated Hebei Medical University,Shijiazhuang 050011,China  
Objective To analyze the histopathological features of non-small cell lung cancer treatment with paclitaxel liposome injection as primarily chemotherapy.Methods Consecutive selected 40 cases with non-small cell lung cancer at grade IIIB,were divided into control group and treatment group randomly.The surgery was executed immediately in control group,while the paclitaxel liposome injection was administrated as primarily chemotherapy for 1 month in treatment group.The pathological analysis were compared between two groups,with HE staining and electron microscope methods.Results (1)There were 13 cases with grade I,II and 3,4 cases with grade III,IV non-small cell lung cancer in treatment group,while there were 0 cases with grade I,II and 6,14 cases with grade III,IV.The therapeutic effect showed statistical significant difference between two groups (P0.05).In addition,the necrosis of tumor cells was obvious in treatment,and improving cellular vacuolar degeneration,pyknosis and coagulation necrosis was obvious too.There was large amount of lymphocytes and acidophilic cellular infiltration around tumor tissue.(2)The survival ratio,T cell subtype ratio and side effect between two groups had no difference (P0.05).(3)The therapeutic effect had no relationship with the patients' gender and age (r=0.284,P0.05),while had closely correlation with type of the tumor (P0.05).Conclusion It could inhibit tumor growth by primary chemotherapy with paclitaxel liposome,and it worthy to applying in clinical treatment.
【CateGory Index】: R734.2
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