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《Chinese Journal of Difficult and Complicated Cases》 2009-07
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The relationship between the T lymphocyte subsets expression and pathological changes in liver tissues in HBV carriers

REN Gui-fang,LI Bing-shun,WANG Wei,et al.The 4th department,the Shijiazhuang 5th Hospital,Shijiazhuang 050021,China  
Objective To observe the changes of the peripheral blood T lymphocyte subsets and its relation-ship with pathological changes in HBV carriers.Methods Histopathological examinations were performed in 79 asymptomatic HBV carriers.Flow cytometer was used to detect the peripheral blood T lymphocyte subsets in asymptomatic HBV carriers and 22 controls.Results (1) The percentage of CD+4 cells and the value of CD+4/CD+8 were significantly reduced in non-active HBV carriers and in chronic HBV carriers than in the normal controls (P0.05 or P0.01).However,the percentage of CD+8 cells was significantly increased (P0.05 or P0.01).(2)No significant differences of the percentage of CD+4、CD+8 cells were observed between nonactive HBsAg carriers and chronic HBV carriers (P0.05). (3)Compared with G0~2,the percentage of CD+4 cells was significantly increased in G3~4 in chronic HBV carriers (P0.05).Conclution Patients with asymptomatic HBV carriers are abnormal in cellular immunity,which may be associated with HBV persistent infection.
【CateGory Index】: R512.62
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