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《Chinese Journal of Difficult and Complicated Cases》 2010-06
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The clinical research of treatment for functional abdominal pain syndrome:Behavior therapy and oral paroxetine therapy

WANG Tao,HOU Peng.Department of Gastroenterology,The First Affiliated Hospital of the PLA General Hospital,Beijing 100048,China  
Objective To investigate the relationship between the symptoms and psychological situation of patients with functional abdominal pain syndrome(FAPS),and compare the behavior therapy and oral paroxetine therapy in the treatment of FAPS.Methods To evaluate the psychological status in patients and normal volunteers with symptom checklist(SCL-90),and compare with domestic mode.The patients with FAPS were randomly assigned to the relaxation behavior therapy group and the oral paroxetine group,the score of FAPS symptom(severity and influence degree) and related factors in each patient before and after treatment were recorded,sample non-parameter test was applied for the statistical analysis.Sex,menopause or not,age,education level,economic conditions,current work and life satisfaction degree,whether have major negative events in recent 6 months were recorded,non-conditional Logistic regression was used to analyze risk factors.Results The positive value of FAPS by SCL-90 evaluation was significantly higher than the normal volunteers,and part of factorial score was higher than the domestic mode,anxiety factor was significantly correlated with the FAPS symptom(P0.05).After 2 weeks treatment,the effect in paroxetine group was better than relaxation therapy group in comparison with intra-and inter-groups.After 8 weeks treatment, there are significant difference intra-groups of relaxation therapy and oral paroxetine therapy in release symptom and improve anxiety factor score(P0.01).There was no statistical difference between groups(P0.05).Non-conditional Logistic regression analysis shows negative event was related risk factor.Conclusion Short term improvement of FAPS by oral paroxetine is better than behavioral therapy,after 8 weeks treatment,follow up evaluation of the overall efficacy of two methods shows no significant difference.Relaxation behavior therapy is prone to accept by patients and cost/benefit ratio is better than oral medication.
【CateGory Index】: R57
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