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《Chinese Journal of Difficult and Complicated Cases》 2010-06
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Effect of sodium ferulate on gastric mucosal cellular apoptosis after traumatic shock resuscitation in rabbits

LV Yan-xia~*,LI Hai-ying,XIONG Ying-fen.* Department of Anesthesiology,Third Affiliated Hospital of Hebei Medical University,Shijiazhuang 050051,China  
Objective To investigate the effects of sodium ferulate on cellular apoptosis and expression of apoptosis related protein Bcl-2 and Bax in gastric mucosa after traumatic shock resuscitation.Methods Sixty healthy rabbits were randomly divided into four groups with 15 in each group:control group(group A),model group(group B),before resuscitation sodium ferulate trerapy group(group C),and after resuscitation sodium ferulate therapy group (group D).The traumatic resuscitation gastric mucosal injury model was established.In group C and D,sodium ferulate 30 mg/kg was injected intravenously 20 min before resuscitation and 30 min at resuscitation respectively.The drug was replaced with equal volume of physiological saline in group A and B.TUNEL technique was applied to examine the apoptotic index(AI) in the gastric mucosa cells.The gray values of Bcl-2 and Bax protein expression were detected by immunohistochemical assay.Results In group B,the AI and the expression gray of Bcl-2 and the expression gray ratio of Bcl-2/Bax were significantly increased,while the expression gray of Bax was significandy decreased compared with those in group A(P0.05 or P0.01).In group C and D,the AI and the expression gray of Bcl- 2 and the expression gray ratio of Bcl-2/Bax were significantly decreased,while the expression gray of Bax was significantly increased compared with those in group B(P0.05 or P0.01).In group D,the AI and the expression gray of Bcl-2 and the expression gray ratio of Bcl-2/Bax were significantly increased,while the expression gray of Bax was significantly decreased compared with those in group C(P0.05).Conclusion It demonstrated that the sodium ferulate could inhibit cellular apoptosis of gastric mucosa induced by traumatic shock resuscitation by up-regulating Bcl-2 protein expression and down-regualting Bax protein expression and increasing the expression ratio of Bcl-2/ Bax,and the remedial effects was better before resuscitation than after resuscitation.
【Fund】: 河北省科技支撑计划项目(No.09276102D-12)
【CateGory Index】: R459.7
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