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《Chinese Journal of Difficult and Complicated Cases》 2010-07
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Therapeutic effect of atorvastatin on the expression of angiotensin converting enzyme 2 in carotid common ar- tery of spontaneously hypertensive rats

CAO Xiao-xia~*,LI Jun,WANG Jun-yuan,et al.*Department of Inter- nal Medicine,Jingxian County Hospital,Jingxian 242500,China  
Objective To observe the effect of atorvastatin on the expression of ACE 2 on intimal hyperplasia of carotid common artery in SHR,and to explore the possible mechanism of atorvastain on vascular remodeling.Met hods Thirteen weeks old male SHR(n=24) were randomized divided into three groups(n=8,each),SHR control group(0.5%acacia mucilage,15 mg·kg·d~(-1)),atorvastatin treatment group(30 mg·kg~(-1)·d~(-1)) and valsartan treatment group(20mg·kg~(-1)·d~(-1)).Eight age matched male Wistar-Kyoto rats were selected as the normal control(WKY group,0.5%acacia mucilage,15mg·kg~(-1)·d~(-1)).Four weeks later,the rats were executed. The levels of plasma angiotensinⅡ(AngⅡ) in carotid common artery were detected by radioimmunoassay.Lumen cross section area(LA),intraelastic layer area(IELA) and extraelastic layer area(EELA) were measured by computed video processing,and the ratio of(IELA-LA)/(EELA-IELA) was calculated.The expression of ACE 2 protein was determined by immunohistochemistry method.The expression of ACE 2 mRNA was evaluated by RT-PCR.Results (1) Compared with normal control,the hyperplasia of intima was markedly inhibited both in atorvastatin group and valsartan group(P0.01).No change of media hyperplasia area was validated in all groups(P0.05).(2) Compared with SHR control group,the level of AngⅡin carotid was decreased in atorvastatin and valsartan treatment group(P0.01),whereas the level of plasma AngⅡ,the expression of ACE 2 mRNA and protein were raised markedly(P0.01),and it's more obviously in valsartan treatment group(P0.05,P0.01).Conclusion Atorvastatin could inhibit hyperplasia of intima in carotid common artery,which may be related to cut down the level of AngⅡin carotid artery,and upregulate the expression of ACE 2 mRNA and protein.
【CateGory Index】: R544.1
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【Citations】
Chinese Journal Full-text Database 6 Hits
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【Co-citations】
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1 HAO XIAO-YAN,TIAN JIAN-HUI,ZHAO HUI(Department of Cardiology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);EFFECT OF ROSVASTATIN ON INFLAMMATORY CYTOKINE IN PATIENTS WITH STABLE ANGINA UNDERGOING PERCUTANEOUS CORONARY INTERVENTION[J];Acta Academiae Medicinae Qingdao Universitatis;2010-04
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