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《Chinese Journal of Difficult and Complicated Cases》 2010-07
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The expression of CD_4~+ invariant T cell receptor and natural killer T cells in the experimental allergic rhinitis

WANG Kai~*,ZHENG Chun-quan,QIU Jian-he.*Department of Otorhinolaryngology,Changzhou First People's Hospital,Jiangsu,Changzhou 213003,China  
Objective To explore the CD_4~+ iNKT cells infiltration in the nasal mucosa of experimental allergic rhinitis mice.Methods Thirty C57BL/6 mice were randomly divided into A(allergic rhinitis group),B(control group).All animals' symptom score,the number of EOS and histological morphous were evaluated and compared. The express of enhanced fluorescence proteins corresponding to CD_4 and NK1.1 was detected by immunoenzymatic technique.The positive rate of the iNKT cells in CD_4~+ cells was detected by flow cytometry(FCM).Results(1) Symptom score:The score in group A(7.3±1.0) was significantly higher than that in group B(0.7±0.6,P0.01).(2) The number of eosinophils in the epithelium:EOS in group A(7.5±1.2) was significantly more than that in group B(0.4±0.5,P0.01).(3) Histological morphous:group A showed:cilia defluxion,tissue dropsy, vascular proliferation and EOS infiltration.No phenomena were ovserved in group B.(4) The express of enhanced fluorescence proteins corresponding to CD_4 and NK1.1 in group A:many CD_4~+ iNKT cells located in the mucosa,and only several CD_4~+ T cells located in the mucosa in group B.(5)FCM:the positive rate of CD_4~+ iNKT cells in group A (72.6%±7.9%) was significantly higher than that in group B(0.49%±0.01%,P0.01).Conclusion It suggested that the CD_4~+ natural killer T cells played a prominent pathogenic role in experimental allergic rhinitis.
【CateGory Index】: R765.21
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【Co-citations】
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1 BAI Lu;LI Weidong;ZHU Xingyu;LIU Ling;XU Shengqiu;Department of Pharmacy,Xuzhou First People's Hospital;Jiangsu Key Laboratory of Chinese Medicine Processing,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing,Nanjing University of Chinese Medicine;;Effects of xanthatin on ovalbumin-induced allergic rhinitis in rats[J];徐州医科大学学报;2017-08
2 ZHANG Mei-xing;XIE Yi-lin;LENG Bei-zheng;QIAO Zhong-dong;WANG Lian-yun;YAN Xiao-mei;School of Life Sciences & Biotechnology,Shanghai Jiaotong University;Shanghai the Fifth People's Hospital;;Establishment of the Mice Model of Allergic Rhinitis Induced by Camphor Tree Pollen[J];实验室研究与探索;2015-09
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6 YAO Yuting;YAN Daonan;Nanjing University of Chinese Medicine;;Effect of Bi Mingan Recipe in Rats with Allergic Rhinitis[J];中药新药与临床药理;2015-03
7 YANG Gui-jun;XI Ke-hu;CHEN Xiao-wan;GUI Yan;WANG You-hu;ZHANG Fu-hong;MA Chun-xia;HONG Hao;LIU Xiang-yi;MA Yi;JIANG Ying;DONG Ming;ZHANG Xiao-bing;Depart-ment of Otolaryngology ,Head and Neck Surgery ,First Hospital of Lanzhou University;Department of Otolaryngology ,Head and Neck Surgery ,Affiliated Hospital ,Gansu College of Traditional Chinese Medicine;;Effect of 18-β Glycyrrhetinic Acid on the Endoplasmic Reticulum of Nasal Epithelial Cells in Allergic Rhinitis Model Rats[J];中国中西医结合杂志;2015-05
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3 WANG Kai~*,ZHENG Chun-quan,QIU Jian-he.*Department of Otorhinolaryngology,Changzhou First People's Hospital,Jiangsu,Changzhou 213003,China;The expression of CD_4~+ invariant T cell receptor and natural killer T cells in the experimental allergic rhinitis[J];疑难病杂志;2010-07
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