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《Chinese Journal of Difficult and Complicated Cases》 2010-07
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The expression of CD_4~+ invariant T cell receptor and natural killer T cells in the experimental allergic rhinitis

WANG Kai~*,ZHENG Chun-quan,QIU Jian-he.*Department of Otorhinolaryngology,Changzhou First People's Hospital,Jiangsu,Changzhou 213003,China  
Objective To explore the CD_4~+ iNKT cells infiltration in the nasal mucosa of experimental allergic rhinitis mice.Methods Thirty C57BL/6 mice were randomly divided into A(allergic rhinitis group),B(control group).All animals' symptom score,the number of EOS and histological morphous were evaluated and compared. The express of enhanced fluorescence proteins corresponding to CD_4 and NK1.1 was detected by immunoenzymatic technique.The positive rate of the iNKT cells in CD_4~+ cells was detected by flow cytometry(FCM).Results(1) Symptom score:The score in group A(7.3±1.0) was significantly higher than that in group B(0.7±0.6,P0.01).(2) The number of eosinophils in the epithelium:EOS in group A(7.5±1.2) was significantly more than that in group B(0.4±0.5,P0.01).(3) Histological morphous:group A showed:cilia defluxion,tissue dropsy, vascular proliferation and EOS infiltration.No phenomena were ovserved in group B.(4) The express of enhanced fluorescence proteins corresponding to CD_4 and NK1.1 in group A:many CD_4~+ iNKT cells located in the mucosa,and only several CD_4~+ T cells located in the mucosa in group B.(5)FCM:the positive rate of CD_4~+ iNKT cells in group A (72.6%±7.9%) was significantly higher than that in group B(0.49%±0.01%,P0.01).Conclusion It suggested that the CD_4~+ natural killer T cells played a prominent pathogenic role in experimental allergic rhinitis.
【CateGory Index】: R765.21
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