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《Chinese Journal of Difficult and Complicated Cases》 2010-08
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The therapeutic effect of high-dose atovastatin in elderly female patients with acute coronary syndrome

HAN Hong-yan~*,YANG Jing.*Department of Cardiology,Tianyou Hospital Affiliated Wuhan Science and Technology University, Wuhan 430064,China  
Objective To investigate the safety and efficacy of high-doses atovastatin in elderly female patients of acute coronary syndrome(ACS) in early stage.Methods Consecutive 102 elderly female patients with ACS were divided into two groups randomly(51 cases per group),the treatment group was given 40 mg/d atovastatin,and the control group was given 20 mg/d atovastatin.The efficacy of atovastatin therapy,the cardiovascular events and drug adverse reaction were recorded in one months follow-up.Results Compared to those before treatment,the level of LDL-C,TC and hs-CRP decreased and the level of HDL-C increased significantly at 1 month after treatment in both groups(P0.05).There was significant difference in TC、LDL-C and hs-CRP between the two groups after treatment (P0.05).Compared to control group,the occurrence of the cardiovascular events was significantly reduced in intensive treatment group(33.3%vs 17.6%,P0.05).There were slightly adverse effect in both two groups. Conclusion The earlier and stronger lipid lowering treatment could improve the prognosis of ACS and make benefits for the patients with ACS.
【CateGory Index】: R541.4
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【References】
Chinese Journal Full-text Database 1 Hits
1 Song Shujiang,Xu Jinpeng,Zhou Yujuan (Hebei University,Baoding 071002,China);Effects of combined nicotinic acid with simvastatin for the vulnerability in experimental atherosclerotic plaques[J];医学研究与教育;2010-05
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 HAN Hong-yan~*,YANG Jing.*Department of Cardiology,Tianyou Hospital Affiliated Wuhan Science and Technology University, Wuhan 430064,China;The therapeutic effect of high-dose atovastatin in elderly female patients with acute coronary syndrome[J];疑难病杂志;2010-08
2 LI Jing,ZHAO Shui-ping,YANG Jun,DONG Shao-zhuang,ZHOU Hong-nian(Department of Cardiovasology, Second Xiangya Hospital,Central South University,Changsha 410011);Effect of niacin on adiponectin levels in the adipocytes secretion in rabbits[J];中南大学学报(医学版);2007-03
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