The short term therapeutic effect of rh-BNP on the chronic systolic heart failure
WANG Xin,WANG Xing, YANG Sheng,et al.The Department of Gerontology of Wannan Medical College Affiliated Yijishan Hospital,Anhui,Wuhu 241001,China
Objective To evaluate the short term therapeutic effect and safety of recombinant human brain natriuretic peptide(rh-BNP) in treatment of chronic systolic heart failure.Methods Thirty-one patients with chronic systolic heart failure were randomly divided into two groups:routine therapy group and rh-BNP group.The patients in routine therapy(n =17) group were administrated with cardiotonic,diuresis,ACEI/ARB,and/orβ-receptor blockers,and the patients in rh-BNP group(n = 14) were applied with rh-BNP(1.5～2.0μg/kg,iv.) based on conventional treatment.The left ventricular ejection fraction(LVEF),concentration of serum BNP and rating of NYHA were observed and compared between two groups during 1～7 month follow up.Results Compared with the routine therapy group,the rating of NYHA in rh-BNP group was significantly and rapidly improved(26 h±9 h vs 36 h±15 h,P0.05),while the LVEF and serum BNP had no significant change(P0.05).No side effects was found in rh-BNP group.Conclusion It demonstrated that the rh-BNP has well therapeutic effect on chronic systolic heart, and the safety was reliable.
【CateGory Index】： R541.6