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《Chinese Journal of Difficult and Complicated Cases》 2010-12
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The effect of ischemic postconditioning on the ischemia reperfusion injury in hind limb of rats model

ZHANG Yan-rong,WU Wen-xin,ZHANG Feng,et al.Department of Vascular Surgery,the Second Hospital Affiliated to Hebei Medical University,Shijiazhuang 050000,China  
Objective To discuss the protective effect of ischemic postconditioning in ischemic reperfusion (I/R) of hind limb in rats model.Methods Fifty-four Wistar male rats was used to establish I/R model.The rats were divided into 3 groups with 18 rats in each group with 3 time points;A was I/R group;B was I/R with one minute reperfusion and one minute ischemia and repealed three times before reperfusion;C was I/R with ten minutes ischemia and ten minutes reperfusion and repeated three times before reperfusion.Then we performed examinations on serum level of LDH,ICAM-1,and the contents of MDA in muscle tissue at 1,3,9 hours after reperfusion.The indexes were compared intro-and inter-groups.Results The serum level of LDH,contents of MDA in muscle,and serum level of ICAM-1 were increased obviously in 3 groups,and there were statistical significance in different time points(P0.01).Furthermore,the indexes in B group were lower than those of in A group(P0.01),except of the serum level of ICAM-1 in time points 1 hour.There was no difference between A group and C group in different time points(P0.05).Conclusion It suggested that short time and multiple times ischemia/reperfusion may inhibit the reperfusion injury in hind limb of rats model.
【Fund】: 河北省卫生厅重点科技研究计划(No.20090397)
【CateGory Index】: R363
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