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《Chinese Journal of Difficult and Complicated Cases》 2010-12
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The Expression of Caspase-8 protein in laryngeal carcinoma and the relation between Caspase-8 and apoptosis

LI Lian-he,FENG Xiu-ling,ZHANG Xiao-wei,et al.Department of Otolaryngology,the Affiliated Hospital of Chengde Medical College,Hebei,Chengde 067000,China  
Objective To investigate the expression of Caspase-8 in laryngeal carcinoma and analyze the relation of Caspase-8 and apoptosis.Methods We measured the expression of Caspase-8 protein in 45 laryngeal carcinoma fresh samples and 45 para-carcinoma tissues(to cutting margin0.5cm) and 20 normal laryngeal mucosa samples by flow cytometere(Epics-XLⅡ),the apoptosis rate was also examined simultaneously.Results(1) The quantitative and qualitative expression of Caspase-8 protein in laryngeal carcinoma tissues is obviously lower than those in para-carcinoma and in normal laryngeal mucosa tissues respectively(P0.01).There is no significant difference between the expression of para-carcinoma and normal laryngeal mucosa tissues(P0.05).(2) In laryngeal carcinoma,the expression of Caspase-8 protein wasnt significantly related to patients' clinical classification,tumor size,smoking history,patients' age and sex(P0.05) but related to metastasis,pathological grade and clinical stage(P0.05).(3) The apoptosis rate in laryngeal carcinoma wasnt related to patients' clinical classification, tumor size,smoking history,patients' age and sex and pathological grade,but related to lymph nodes metastasis and clinical stage.(4) In laryngeal carcinoma,there was a positive correlation between the apoptosis rate and FI of Caspase-8(P0.01).Conclusion The low expression and inhibition of apoptosis of Caspase-8 may contribute to the carcinogenesis and development of laryngeal carcinoma.
【CateGory Index】: R739.65
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