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《Chinese Journal of Difficult and Complicated Cases》 2013-01
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Systematic reviews in different prognosis of levetiracetam treatment with senile epilepsy

XU Li-li,WANG Yun-fu, SUN Yan-peng.Department of Neurology,Taihe Hospital,Hubei,Shiyan 442000,China  
Objective To evaluate the efficacy of levetiracetam in the treatment of senile epilepsy.Methods Nearly 10 years data were search by Cochrane Library,Medline,PubMed,Web of Science,CECDB,CQVIP,CNKI,included evaluation study.Researchers critical appraisal,data extraction and quality of included studies,Evaluation review were managed by software 5.0 on the RCT line systems that meet quality standards.Results 6 RCT of 283 patients were included in this study,the treatment group(use LEV)of 144 cases,control group(use LTG,TPM,OXC,GBP)of 139 cases.Two groups of patients also were given the symptomatic supportive treatment.Systematic reviews results showed that there were significant differences of the number of seizures in patients within 3 months(RR=-1.40,95%CI-1.73 ~-1.08,P 0.01)and 6 months(RR=-2.07,95%CI-2.44~-1.70,P 0.01)between the treatment group and control group.The number of patients with impaired liver function(RR=0.39,95%CI 0.19 ~ 0.84,P 0.01)and kidney function(RR=0.36, 95%CI 0.15~0.84,P 0.01)within 6 months also were statistical different between the two groups.No significant difference was found between 2 groups in mortality rate(RR=1.06,95%CI 0.64 ~ 1.77,P 0.05).Conclusion Levetiracetam can significantly improve the efficacy of treating senile epilepsy,and does not increase the risk of death in patients with nervous system disorders.
【CateGory Index】: R742.1
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