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《Chinese Journal of Difficult and Complicated Cases》 2013-01
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Effects of butylphthalide on thromboxane A_2,prostacyclin and antithrombin Ⅲ in treatment of acute cerebral infarction

CHANG Huan-xian,LIU Li-yan,WANG Yi-cui,et al.Department of Neurology,Dongfang Hospital,Jiangsu Province, Lianyungang 222042,China  
Objective To observe the influence of butylphthalide on curative effect and butylphthalide thromboxane A_2,prostacyclin and antithrombinⅢin treatment of acute cerebral infarction.Methods 100 cases of acute cerebral infarction were randomly divided into control group(50 cases)and butylphthalide group(50 cases).The control group received conventional treatment.The butylphthalide group received butylphthalide treatment on the basis of the control group.Course of treatment was 21 days in two groups.To detect neurological deficit score(NIHSS),activities of daily living score(Barthel index), infarct volume,thromboxane A_2,prostacyclin and antithrombinⅢin patients of two groups before and after treatment. Results 21 days after treatment,the total effective rate in the butylphthalide group was higher than that in the control group (90.0%vs 74.0%,P 0.05);NIHSS score,Barthel index,infarct volume,TXB_2,6-Keto-PGF1αand AT-Ⅲin the butylphthalide group were significantly better than that in the control group(P 0.01 or P 0.05).The side effects of butylphthalide was much milder.Conclusion It is safe and effective that butylphthalide combined with traditional medicines in treatment of acute cerebral infarction,which can significantly improve neurological function and activities of daily living,reduce the size of the infarct,reducing thromboxane A_2,prostacyclin and antithrombinⅢlevels.
【CateGory Index】: R743.3
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