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《Chinese Journal of Difficult and Complicated Cases》 2013-01
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The study of blood coagulation status in type 2 diabetes mellitus

MU Zhi-jing,WANG Li.Department of Endocrinology, Xuanwu Hospital,Capital Medical University,Beijing 100053,China  
Objective To explore the changes and clinical significance in coagulation anti-coagulation and fibrinolysis system in patients with type 2 diabetes mellitus(DM).Methods To measure thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),and fibrinogen(Fib),anti-thrombinⅢ(AT-Ⅲ),protein C(PC),protein S (PS)in 311 patients with type 2 diabetes mellitus from 2010 to 2011.These patients were categorized as single DM group, DM with hypertension group,DM with coronary heart disease group.At the same time,30 healthy people were selected as contrast group.SPSS software was used for statistic analysis.Results The activity of AT-Ⅲ,PC,PS of type 2 diabetes mellitus were progressively lower than those of control group.There was a significant difference between single DM group and DM with coronary heart disease group.The level of APTT,PT had shortened compared with normal controls.The level of plasma Fib of type 2 diabetes had raised significantly than that of normal controls.Conclusion Coagulation function was disordered in patients with type 2 diabetes mellitus;especially those with vascular complications.AT-Ⅲ,PC,PS,APTT,PT,Fib were helpful for evaluating coagulation function.It would be important for the diagnosis and therapy of hyper-coagulable state in DM patients.
【CateGory Index】: R587.1
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