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《Chinese Journal of Difficult and Complicated Cases》 2013-06
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Protective effect of captopril against contrast-induced nephropathy in elder patients with coronary heart disease

LI Nan,YAN Yan,HAN Jing.Emergency Center for Heart,Lung and Vessel Diseases,Beijing Anzhen Hospital,Capital Medical University, Beijing 100029,China  
Objective To evaluate the protective effect of captopril against contrast-induced nephropathy in elder patients with coronary heart disease.Methods A total of 123 elder patients(60 years) with coronary heart disease undergoing coronary artery angiography were randomly assigned into captopril group and control group to receive captopril or placebo,respectively, before and after administration of the contrast agent.Results In both groups,the contrast agents obviously affected the renal functions of the patients(P 0.05).At 48h after contrast administration,the level of serum creatinine was significantly higher in captopril group than in the control group,while creatinine clearance rate and glomerular clearance rate was lower(P 0.05).At 72h after contrast administration,the glomerular and tubular functional parameters were all superior in both groups.Of the 123 patients,6 experienced CIN,and the overall incidence was 4.87%(6/123).The incidence of contrast agent induced nephropathy was significantly lower in captopril group than in the control group(3.39%vs 6.25%,P 0.05).Conclusion Captopril offers protection against radiographic contrast agent induced renal injury in elderly patients with coronary heart disease.
【Fund】: 教育部重点实验室项目(No.2012XXGB04)
【CateGory Index】: R541.4
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