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《Chinese Journal of Difficult and Complicated Cases》 2013-11
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Comparison of irbesartan and enalapril for treating patients with acute myocardial infarction

DUAN Ban-yan;DANG Shu-yi;ZHOU Ming;Department of Cardiology,Taihe Hospital,Affiliated of Hubei University of Medicine;  
Objective To investigate the effects of irbesartan and enalapril on patients with acute myocardial infarction(AMI).Methods 86 patients with AMI were randomly divided into the irbesartan group(n = 40) and the enalapril group(n =46).Each group was given traditional treatment and related medicine(irbesartan or enalapril) for 2 months and followed up for 6 months.Conventional index,like:Blood pressure,heart rate,lipid,ultrasound,high sensitive C reactive protein(hs-CRP),brain natriuretic peptide(BNP),and matrix metalloproteinase-2,-9(MMP-2,-9) and adverse cardiovascular events were recorded.Results After treatment,the improvement for lipid,hs-CRP and BNP was occurred in both groups(P 0.05).In the 60th day,there were no difference between the two group in conventional index(P 0.05),but the MMP-2,-9 levels in irbesartan group were much lower than those in enalapril group(P 0.05);No differences of cardiovascular events incidence were happened in the two groups within six months follow up(P 0.05).Conclusion Both the irbesartan and enalapril are benefit for the AMI;The effect of irbesartan on AMI is not inferior to enalapril;irbesartan might be used as an alternative medicine for ACEI.
【CateGory Index】: R542.22
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