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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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The effect of ticagrelor on contrast induced nephropathy in acute coronary syndrome patients underwent emergency percutaneous coronary intervention

ZHENG Xueyang;LI Na;HUANG Zhigang;TANG Zhen;WANG Liming;Department of Renal Transplantation,Second Military Medical University Affiliated Changzheng Hospital;  
Objective To compare the effect of ticagrelor and clopidogrel on contrasl induced nephropathy(CIN) in acute coronary syndrome patients underwent emergency percutaneous coronary intervention(PCI).IVIethods Clinical data of221 acute coronary syndrome patients who had received emergency PCI was retrospectively analyzed,118 cases in the ticagrelor group,103 cases in the elopidogrel group.The serum creatinine(SCr),estimate glomerular filtration rate(eGFR)and CIN incidence of before PCI or 72 hours after PCI from patients in both groups were compared.Results The general data and medication of both groups were comparable.The SCr and incidence of CIN after PCI in licagrelor group were higher than those in elopidogrel group[SCr:(112.0 ± 23.2) μmol/L vs.(106.5 ± 19.7) μmol/L,t = 1.834,P = 0.068;CIN;6.8%vs.4.8%,x~2 =0.368,P =0.544],and the eGFR in ticagielor group was lower than that in the elopidogrel group[(81.4 ±21.5) ml/min~(-1) · 1.73m~(-2) vs.(83.2±20.3) ml/min~(-1) · 1.73m~(-2),t =0.637,P =0.525),but the differences were not statistically significant(P 0.05).Analysis of the two groups of patients with moderate to severe renal insufficiency showed higher SCr(133.3±12.1 μmol/L vs.126.0 ± 12.lμmol/L,t =2.140,P =0.038) and lower eGFR(42.3 ±6.2 ml/min~(-1) ·1.73m~(-2) vs.46.7 ±7.5 ml/min~(-1)· 1.73m~(-2),t =2.246,P =0.029) in ticagielor group than those in elopidogrel group,the difference was statistically significant(P 0.05).The incidence of CIN was higher in the patients with moderate to severe renal insufficiency in ticagrelor group than those in elopidogrel group,however,there was no statistical significance(P 0.05).Conclusion In all patients with ACS who underwent emergency PCI,the general incidence of CIN in ticagielor group and elopidogrel group had no difference.However,increased incidence of CIN was observed in patients with moderate to severe renal insufficiency in ticagrelor group.Prophylactic treatments should be helpful to these patients in the perioperative period.
【Fund】: 国家自然科学基金资助项目(81303111)
【CateGory Index】: R541.4
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【References】
Chinese Journal Full-text Database 3 Hits
1 Jin Peng;Li Lin;Hu Xin-rong;Cai Ji-rui;Li Sheng-jun;Yang Guang;Department of Internal Medicine-Cardiovascular, the Central Hospital of Luohe City;;Comparative Analysis of Effects of Ticagrelor and Clopidogrel on Platelet Function, Inflammatory Factors and Long-term Prognosis in Patients with Acute Coronary Syndrome after PCI[J];中国合理用药探索;2017-07
2 YE Shi-quan;MA Dong-ming;YANG Jun;Department of Cardiology,the People's Hospital of Santai County,Mianyang;Department of Cardiology,the People's Hospital of Langzhong;;Impact of Danhong Injection Combined with Clopidogrel on Postoperative Serum Levels of ET-1 and NO in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention[J];实用心脑肺血管病杂志;2017-06
3 YI Xin;GUO Wei;LIU Liwen;Department of Laboratory,Jining First People's Hospital;;Effects of telmisartan on oxidative stress and vascular endothelial function in patients with coronary slow flow[J];疑难病杂志;2017-05
【Citations】
Chinese Journal Full-text Database 6 Hits
1 Lu Rui;Deng Kewu;Zhang Wenchao;Yao Min;Department of Cardiology,Beijing NO.6 Hospital;2 Ward,Department of Cardiology,Beijing Tongren Hospital,Capital Medical University;50 Ward,Fuwai Hospital,Chinese Academy of Medical Sciences;;A comparative study of intensive statins in the prevention of contrast-induced nephropathy[J];中国医药;2016-07
2 WU Ying;HE Yun;HUANG Wenhan;SHEN Zhaonan;SU Yong;Department of Nephrology,the Fifth People's Hospital of Chongqing City;;The preventive effect of alprostadil lipo preparation on contrast induced nephropathy in patients with PCI[J];疑难病杂志;2016-02
3 LI Jingfang;CHANG Liang;JIA Yan;YANG Rong;Department of Internal Medicine,Zhengding County People's Hospital of Hebei Province;;Protective effect of compound Danshen dripping pills on intervention after percutaneous coronary intervention in patients with contrast agent in renal damage[J];疑难病杂志;2015-06
4 LI Yan;WANG Li-zhong;ZHANG Chun-lai;Department of Cardiology,Tangshan Worker Hospital;;Effect and Safety of Ticagrelor on Patients With Unstable Angina Undergoing Selective Percutaneous Coronary Intervention[J];中国全科医学;2015-15
5 LOU Shan-jie;HUANG Cheng-yi;ZHU Jin-cao;ZHONG Ji-fang;MAO Ying-li;LIU Xu;Department of Cardiology,Aiyimei Hospital of Fenghua;;Effect of ticagrelor on acute coronary syndrome[J];中华实用诊断与治疗杂志;2015-01
6 HUO Yang;CHU Wei-wei;JIA Da-lin;SONG Tao;CHEN Yue;ZHAO Yue-ping;SUN Nan;The First Department of Internal Medicine,General Hospital of Liaoning Provincial Armed Police Force;Department of Cardiology,the First Hospital Affiliated to China Medical University;;Influence of Different Doses of Rosuvastatin on Levels of Serum C-reactive Protein,Uric Acid and Blood Lipid of Patients with Acute Coronary Syndrome[J];解放军医药杂志;2014-02
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 WEI Hong-jie;SHI Jun-ting;LI Xing-xing;Department of Cardiology,Central Hospital of China National Petroleum Corporation;;Clinical effect of anti-platelet agents in PCI patients with clopidogrel resistance[J];临床和实验医学杂志;2017-16
2 LI Ning;MA Man-ling;Department of Pharmacy,First Affiliated Hospital of Harbin Medical University;;Analysis on efficacy and safety of ticagrelor versus clopidogrel in treatment of acute coronary syndrome[J];中国医院药学杂志;2017-15
3 QU Hong;Department of Cardiovascular Internal Medicine,Anhui Province Xuancheng Central Hospital;;Effect of Ticagrelor on level changes of serum IL-6,TNF-α after PCI operation[J];现代医学;2017-06
4 LIN Wei;ZHOU Rui;LIN Jian-feng;Department of Cardiology,Wenzhou People’s Hospital;;Efficacy and loading dose analysis of ticagrelor in acute coronary syndrome patients with low on-clopidogrel platelet reactivity and its influence on prognosis[J];中华全科医学;2017-06
5 Guo Hui;First People's Hospital of Xinxiang in Henan Province;;Clinical observation of Wenyang Tongmai decoction combined with clopidogrel in the treatment of unstable angina pectoris[J];陕西中医;2017-06
6 YU Hui;MEI Yibin;ZHANG Wei;Department of Cardiovascular Medicine, Lishui People's Hospital in Zhejiang Province;;Observation of the clinical effect of Shexiang Baoxin pill in the treatment of post-PCI unstable angina pectoris complicated with diabetes[J];中国现代医生;2017-10
7 SUN Chenggong;WANG Yin;ZHU Pin;XU Yingjie;WANG Dong;Tongren Hospital Affiliated to Shanghai Jiaotong University School of Medicine;;Correlation between bone mass and carotid artery intima media thickness in elderly patients with coronary heart disease[J];疑难病杂志;2017-04
8 GUO Hong-yi;LI Zhi-yong;YAN Jie-song;Department of Vasculocardiology,3201 Hospital of Hanzhong;;Clinical Features and Prognostic Analysis for Interventional Therapy in Elderly Patients with Acute Coronary Syndrome[J];解放军医药杂志;2017-03
9 LI Jiang-hua;LIU Wan-hui;Pharmaceutical School,Yantai Univercity;;Application of Ticagrelor for the Treatment of Acute Coronary Syndrome[J];系统医学;2017-02
【Co-references】
Chinese Journal Full-text Database 9 Hits
1 Yan Yan;Wang Xiao;Fan Jingyao;Nie Shaoping;Sergio Raposeiras-Roubín;Emad Abu-Assi;José Paulo Simao Henriques;Fabrizio D'Ascenzo;Jorge Saucedo;José Ramon González-Juanatey;Stephen B.Wilton;Wouter J.Kikkert;Iván Nunez-Gil;Albert Ariza-Sole;Dimitrios Alexopoulos;Christoph Liebetrau;Testuma Kawaji;Claudio Moretti;Zenon Huczek;Toshiharu Fujii;Luis Claudio Correia;Masa-aki Kawashiri;Sasko Kedev;Emergency and Critical Care Center,Beijing Anzhen Hospital,Capital Medical University;Deparment of Cardiology,University Hospital Alvaro Cunqueiro;Department of Cardiology,Academic Medical Center,University of Amsterdam;Department of Cardiology,University San Giovanni Battista Hospital;Department of Cardiology,NorthShore University Hospital;Department of Cardiology,University Clinical Hospital of Santiago de Compostela;Department of Cardiac Sciences Medicine,Libin Cardiovascular Institute of Alberta;Department of Cardiology,San Carlos Hospital;Department of Cardiology,Bellvitge Hospital;Department of Cardiology,University Patras Hospital;Department of Cardiology,Kerckhoff Heart and Thorax Center;Department of Cardiology,Graduate School of Medicine,Kyoto University;Department of Cardiology,University Clinical Hospital;Department of Cardiology,Tokai University School of Medicine;Department of Cardiology,Hospital Sao Rafael;Department of Cardiology,Kanazawa University Graduate School of Medicine;Department of Cardiology,University Clinic of Cardiology;;Effect of clopidogrel combined with proton pump inhibitor on prognosis of acute coronary syndrome after percutaneous coronary intervention[J];中国医药;2017-02
2 SUN Xi-wen;ZHANG Can;LIN Qiu-wei;Department of Cardiology, Gaozhou People's Hospital;;Ticagrelor in patients with acute coronary syndrome interventional treatment of Effect[J];中国循证心血管医学杂志;2017-01
3 ZHENG Xueyang;LI Na;HUANG Zhigang;TANG Zhen;WANG Liming;Department of Renal Transplantation,Second Military Medical University Affiliated Changzheng Hospital;;The effect of ticagrelor on contrast induced nephropathy in acute coronary syndrome patients underwent emergency percutaneous coronary intervention[J];疑难病杂志;2017-01
4 HUANG Ying;HAO Yanli;SUN Ying;ZHANG Huiying;Department of Internal Medicine of Cardiovascular,Liaoning Jinqiu Hospital;;Clinic results and changes in inflammatory cytokines,adhesion molecules of patients with hypertension and diabetes in treatment with telmisartan[J];疑难病杂志;2016-12
5 ZHANG Sheng;SUN Jian-hui;ZHOU Xue-zhong;Department of Cardiology , The First People's Hospital of Changzhou;;Efficacy and safety of ticagrelor and double-dose clopidogrel in patients with acute coronary syndrome resistant to ciopidogrel[J];岭南心血管病杂志;2016-05
6 ZHOU Deng-feng;SHI Yan;Department of Health Care,Hainan Branch of PLA General Hospital;Department of Cardiology,Central 210 Hospital of PLA;;The effect of clopidogrel/ticagrelor on patients with acute coronary syndrome:a 1-year clinical study[J];中国临床医学;2016-03
7 JIA Zhu-yin;QU Xiao-dan;SUN Jia-ju;HUANG Yi-wei;WANG Jun;Department of Cardiology,Wenzhou Central Hospital;;Comparing the effect of clopidogrel versus ticagrelor on coronary microvascular dysfunction in patients with non-ST segment elevation acute coronary syndrome[J];中国介入心脏病学杂志;2016-05
8 MIAO Lifu;CUI Yongliang;YIN Yanping;BAI Yan;LI Jian;WANG Lili;Heart Center,First Hospital of Tsinghua University;;Clinical efficacy and safety evaluation of double-dosage clopidogel and ticagrelor in patients with hyporesponsiveness to clopidogrel[J];临床心血管病杂志;2016-04
9 YAN Liying;ZHNAG Fenglei;YUAN Yan;ZHANG Qi;XU Xinsheng;Emergency Department,Dongying People's Hospital;;A clinical study on the relationship between coronary slow flow and oxidative stress[J];临床心血管病杂志;2016-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHENG Qingkun;LIU Jianxiong;HU Yongmei;Department of Cardiology,Chengdu Second People's Hospital;;The effect of treatment with atorvastatin in different dosage on contrast-induced nephropathy in elder with coronary heart disease after coronary angiography and/or percutaneous coronary intervention[J];临床内科杂志;2015-11
2 CHEN Yuyi;Department of Cardiovasology,Dongguan People's Hospital,Guangdong Province;;Study on effect of intensive Atorvastatin for intervention of contrast induced nephropathy after percutaneous coronary intervention in patients with acute coronary syndrome[J];中国医药导报;2015-18
3 WU Fenfen;FU Xiaomin;HE Kunlun;Chinese PLA General Hospital Medical School of Chinese PLA;Department of Health,the Military General Hospital of Beijing PLA;;Study on intensive Atorvastatin Calcium in preventing radiographic con-trast nephropathy after percutaneous coronary intervention and its relat-ed risk factors[J];中国医药导报;2015-15
4 ZHONG Si-gan;YANG Fei;CHEN Ai-wen;Department of Cardiology,the Third People's Hospital of Huizhou;;The Preventive Effect of Alprostadil on Contrast Nephropathy among the Patients with Coronary Artery Disease Complicated with Diabetes in the Interventional Therapy[J];中国全科医学;2014-31
5 GUO Yan;HOU Huiru;LIU Yuchun;The First Ward of First Heart Division of South Tower, General Hospital of PLA;Department of Nursing, General Hospital of PLA;;Observation and nursing in prevention of contrast induced nephropathy in elderly inpatients with CAD by clinical pathway of nursing[J];中国医药导报;2014-24
6 LI Dan;HAN Lei;Nautical and Aviation Medical Center,General Hospital of PLA Navy;;Effect of Atorvastatin on Oxidative Stress Level of Patients with Diabetic Nephropathy in Primary stage[J];解放军医药杂志;2014-08
7 LI Yi-na;YANG Shi-cheng;FU Nai-kuan;Tianjin Medical University Postgraduate School;;Role of prostaglandin E1 in prevention of contrast-induced nephropathy in elderly CHD patients undergoing PCI[J];中华老年心脑血管病杂志;2014-06
8 LI Zhi-li;CAO Yi-zhan;AI Yong-fei;Department of Cardiology,Tangdu Hospital,the Fourth Military Medical University;;Analysis of the factors and treatment of the acute and subacute thrombosis in the coronary drug-eluting stent[J];中国急救医学;2014-04
9 ZHU Hai;Department of Cardiology, People's Hospital of Beihai City;;Clinical study of N-acetylcysteine in prevention of contrast-induced nephropathy after PCI in elderly patients with acute myocardial infarction[J];中国医药导报;2014-09
10 Wei Chunyan;Luo Min;Xu Ting;Department of Pharmacy,West China Hospital,Sichuan University;;Application of Cilostazol in Antiplatelet Therapy of PCI[J];中国药业;2014-05
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