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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Effect of atorvastatin on serum levels of IGF-I,sE-selectin and TGF-β1 in patients with coronary heart disease after PCI and its significance

YANG Lei;YU Xinguo;LIU Junchao;YU Hanbin;LUO Zuoyang;Shenzhen Baoan District Central Hospital Affiliated to Guangdong Medical College;  
Objective To explore the effect of rosuvastatin in adjuvant treatment of patients with coronary heart disease after percutaneous coronary intervention on the efficacy and serum insulin-like growth factor 1(IGF-1),E selectin(sEselectin),transforming growth factor beta 1(TGF-Sl).Methods One hundred and twenty cases of patients with coronary heart disease according to randomly divided into the observation group(n =60) and control group(n =60),control group was treated with sulfuric acid hydrogen clopidogrel tablets for oral treatment,the obsenation group in the control group on the basis of and service rosuvastatin treatment with a statin,comparative analysis the clinical therapeutic effect of the two groups,observe the two groups before and after treatment two groups of lipid levels,patch size and serum IGF-I and sE-selectin,TGFSl level.Results The total efficiency of the observation group was 96.67%,higher than 83.34%in the control group(x~2=5.926,P 0.05).The obsenation group serum sE-selectin levels than the control group[(9.12 ± 1.52) ng/'ml vs.(22.78 ±3.48)ng/ml,t =23.31,P 0.05],serum IGF-I,and TGF-β1 were higher than the control group[(485.23 ±42.220 mmol/Lvs.(375.25 ±36.69) mmol/L,(118.96 ±32.25) pg/ml vs.(85.69 ± 22.52) pg/ml,t =12.743.t =5.481,P0.05].TG,TC and LDL-C levels alter treatment in the observation group were lower than the control group[(2.06 ±0.76)mmol/L vs.(2.58 ±0.74),mmol/L,(4.05±0.62) mmol/L vs.(5.36±0.58) mmol/L,(3.45 ±0.70) mmol/L vs.(4.22 ±0.62) mmol/L,t =3.860,t =12.349,t =6.484,P 0.05].HDL-C was higher than the control group[(2.88 ±0.65) mmol/L vs.(2.32±0.72) mmol/L,t =4.546,P 0.05 J.The area of plaque and IMT level in the ohservation group were lower than that in the control group[(15.25 ±4.89) mmol/L vs.(5.66±22.02) mmol/L,(0.76±0.22) mm vs.(0.36 ±1.02) mm,t = 7.127,t =4.852,P 0.05].Conclusion Atorvastatin can effectively regulate the level of serum IGF-I,sE-selectin TGF-β1 in patients with coronary heart disease after PCI,reduce atherosclerosis,improve the treatment effect of patients.
【CateGory Index】: R541.4
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