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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Effect of recombinant human brain natriuretic peptide on heart function,BNP,SCr,CRP of elderly patients with heart failure

SUN Ying;HAO Yanli;LI Yanhui;ZHUANG Yuan;LI Yue;Internal Department of Cardiovascular Disease,Liaoning Jinqiu Hospital;  
Objective To observe the clinical efficacy and changes in heart function,BNP,SCr,CRP of elderly patients with heart failure in treatment with recombinant human brain natriuretic peptide.Methods Eighty-two cases of patients with heart failure in Liaoning Jinqiu Hospital internal medicine department were selected,and they were divided into the observation group(41 cases)and control group(41 cases).The patients of control group were treated with conventional therapy.On the basis of control group,the patients of observation group were treated with recombinant human brain natriuretic peptide(initial loading dose(1.5-2.0)μg/kg,intravenously within 3min,then 0.007 5μg·kg~(-1).min~(-1) continuous intravenous infusion for 72h).The patients of two groups were all treated for 7 days.Compare the clinical efficacy,adverse events and changes of the levels of left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),stroke volume(SV),cardiac index(CI),serum brain natriuretic peptide(BNP),C reactive protein(CRP)content,serum creatinine(SCr)of the two groups.Results After the appropriate treatment,the patients of the observation group got a total effective rate of 90.2%,which was significantly better than the 73.2%of the control group(X~2=3.998,P=0.046);In the terms of LVEF,LVESD,BNP,CRP and SCr,the patients of two groups were all significantly improved than before(t=10.411,t=4.710,t=34.623,t=5.942,t=3.128,t=6.593,t=1.761,t=19.126,t=3.732,t=1.768,all P0.05),and the patients of the observation group got more significant improvement(t=4.029,t=3.047,t=25.666,t=3.893,t=1.738,all P0.05);In the terms of LVEDD,SV,CI,there were no significant changes than before in both two groups(t=1.089,t=0.624,t=1.454,t=1.391,t=0.386,t=0.860,t=0.837,t=0.571,t=0.512,all P 0.05);There were orthostatic hypotension,abdominal pain,headache,elevated aminotransferases,elevated serum potassium and other adverse reactions occurred in both two groups during the treatment,and there were no statistically significant between the two groups(x~2=1.075,X~2=0.503,X~2=0.193,X~2=0.889,X~2=0.889,all P 0.05).Conclusion Recombinant human brain natriuretic peptide in adjuvant therapy can improve the clinical effect of elderly patients with heart failure,improve heart function,reduce the renal injury and inflammatory reaction,safe and reliable,is conducive to the rehabilitation of patients,is worthy of clinical application.
【CateGory Index】: R541.6
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