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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Effect of recombinant human brain natriuretic peptide on heart function,BNP,SCr,CRP of elderly patients with heart failure

SUN Ying;HAO Yanli;LI Yanhui;ZHUANG Yuan;LI Yue;Internal Department of Cardiovascular Disease,Liaoning Jinqiu Hospital;  
Objective To observe the clinical efficacy and changes in heart function,BNP,SCr,CRP of elderly patients with heart failure in treatment with recombinant human brain natriuretic peptide.Methods Eighty-two cases of patients with heart failure in Liaoning Jinqiu Hospital internal medicine department were selected,and they were divided into the observation group(41 cases)and control group(41 cases).The patients of control group were treated with conventional therapy.On the basis of control group,the patients of observation group were treated with recombinant human brain natriuretic peptide(initial loading dose(1.5-2.0)μg/kg,intravenously within 3min,then 0.007 5μg·kg~(-1).min~(-1) continuous intravenous infusion for 72h).The patients of two groups were all treated for 7 days.Compare the clinical efficacy,adverse events and changes of the levels of left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),stroke volume(SV),cardiac index(CI),serum brain natriuretic peptide(BNP),C reactive protein(CRP)content,serum creatinine(SCr)of the two groups.Results After the appropriate treatment,the patients of the observation group got a total effective rate of 90.2%,which was significantly better than the 73.2%of the control group(X~2=3.998,P=0.046);In the terms of LVEF,LVESD,BNP,CRP and SCr,the patients of two groups were all significantly improved than before(t=10.411,t=4.710,t=34.623,t=5.942,t=3.128,t=6.593,t=1.761,t=19.126,t=3.732,t=1.768,all P0.05),and the patients of the observation group got more significant improvement(t=4.029,t=3.047,t=25.666,t=3.893,t=1.738,all P0.05);In the terms of LVEDD,SV,CI,there were no significant changes than before in both two groups(t=1.089,t=0.624,t=1.454,t=1.391,t=0.386,t=0.860,t=0.837,t=0.571,t=0.512,all P 0.05);There were orthostatic hypotension,abdominal pain,headache,elevated aminotransferases,elevated serum potassium and other adverse reactions occurred in both two groups during the treatment,and there were no statistically significant between the two groups(x~2=1.075,X~2=0.503,X~2=0.193,X~2=0.889,X~2=0.889,all P 0.05).Conclusion Recombinant human brain natriuretic peptide in adjuvant therapy can improve the clinical effect of elderly patients with heart failure,improve heart function,reduce the renal injury and inflammatory reaction,safe and reliable,is conducive to the rehabilitation of patients,is worthy of clinical application.
【CateGory Index】: R541.6
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 HUANG Jun;GU Xiao-long;DONG Zheng-hua;LEI Hui-yan;GONG Zhi-hua;XIANG Ding-cheng;Graduate School Southern Medical University;Department of Cardiology,Guangzhou General Hospital of Guangzhou Military;Department of Ultrasonography,Guangzhou General Hospital of Guangzhou Military;;Effect of digitalis on left ventricular remodeling after microswine with acute heart failue after acute myocardial infarction[J];中国生化药物杂志;2015-02
2 ZENG Xiao-hua;WANG Jing;TAN Jie;School of Basic Medical Sciences,Guilin Medical University;;Research Progress of Recombinant Human Brain Natriuretic Peptide in the Treatment of Acute Heart Failure[J];医学综述;2015-01
3 LIN Lin;LI Jun;GONG Qing;SHENG Jun-qin;XI Bei-li;Department of Gerontology, Xuhui District Center Hospital;;Correlation between BNP and LVEF, cardiac functional grading and prognosis in elderly patients with heart failure[J];中国循证心血管医学杂志;2014-04
4 Lu Xin;Hu Taohong;Xie Xiaochun;Liu Shenglin;Li Huijun;Zhang Wei;Wang Jing;Department of Cardiology,Second Artillery General Hospital of People's Liberation Army;;Efficacy of recombinant human brain natriuretic peptide on acute heart failure with renal function insufficiency[J];中国医药;2014-08
5 FU Long;GUO Liang;ZHANG Yue-lan;Department of Cardiology,the First Affiliated Hospital of China Medical University;;Clinical Curative Effect of Recombinant Human Brain Natriuretic Peptide on Hemodynamic Changes in Patients with Acute Heart Failure[J];中国全科医学;2014-17
6 CHEN Wei-quan;Department of Cardiology,The People's Hospital of Luoding;;Influence of recombinant human brain sodium peptide on hemodynamics and renal function in treating acute heart failure induced by myocardial infarction[J];岭南心血管病杂志;2014-02
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 XU Zheng-yun;REN Guo-zhen;Department of Cardiology,the People's Hospital of Changzhi;;Clinical effects of recombinant human brain natriuretic peptide on refractory heart failure and observation on the short-term prognosis[J];中国心血管病研究;2018-08
2 Shi Wenjing;Yang Wei;Song Jia;Chen Chunyan;Wu Bin;Department of Cardiovascular Disease,the Third Affiliated Hospital of Zhejiang Traditional Chinese Medical University;;Effect of Zhenwu decoction in the treatment of acute heart failure and its influence on cardiac function,cardiomyocyte apoptosis factor and serum level of brain natriuretic peptide[J];中国基层医药;2018-09
3 Ding Qi;Jiyuan People's Hospital;;Recombinant human brain natriuretic peptide for patients with acute heart failure and its influence on cardiac funtion and adverse events[J];国际医药卫生导报;2018-08
4 Cai Lingwei;Second People's Hospital of Luohe;;Correlation study between brain natriuretic peptide and the severity of chronic heart failure[J];临床心身疾病杂志;2017-04
5 YI Xin;HUA Qi;Department of Cardiology,Xuanwu Hospital of Capital Medical University;;Clinical characteristics of elderly patients with chronic heart failure in different left ventricular ejection fraction[J];中国心血管病研究;2017-07
6 Li Yuping;Department of Cardiology,Changge People's Hospital;;Effects of heparin intervention on platelet-related parameters and vascular endothelial cell function in patients with acute and severe heart failure[J];中国实用医刊;2017-08
7 Sun Lufang;Du Shixiu;Maternal and Child Health Care Hospital of Jiaozhou City;;Expression of plasma B type natriuretic peptide in patients with pregnancy-induced hypertension and its correlation with cardiac function[J];国际医药卫生导报;2016-13
8 LV Bin;Internal Medicine-Cardiovascular Department, People's Hospital of Jiawang District,Xuzhou City;;Clinical study of recombinant human brain natriuretic peptide in acute myocardial infarction patients with pump failure[J];中国医药科学;2015-24
9 WU Yi-qin;HUANG Guan-wen;FENG Xiao-qian;Guangzhou No.12 People's Hospital;;Clinical Value of Plasma Brain Natriuretic Peptide Levels and its Effect on Patients with Congestive Heart Failure[J];黑龙江医学;2015-12
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Hexi;GONG Hui;Department of Cardiology,Jinshan Hospital,Fudan University;;Atrial fibrillation complicating digitalism and splenic infarction:one case report[J];临床心血管病杂志;2014-05
2 GAO Zhen.Department of Cardiology,Wandong People's Hospital,Chuzhou 339000,Anhui,China;Changes of Plasma Brain Natriuretic Peptide Levels in Patients with Heart failure[J];中华全科医学;2013-03
3 ZHANG Li-bo. Department of Cardiology, Dongguan Municipal Changping Hospital, Dongguan 523573, China.;Clinical application of rhBNP in patients with acute left heart failure[J];中国循证心血管医学杂志;2012-06
4 YAN Ming-chang, ZHAO Chun-zhi, ZHANG Dong-ju. Department of Cardiology, Zhejiang Si’an International Hospital,Jiaxing 314031, China;Correlation of 6-minute walk test,brain natriuretic peptide, left ventricular end-diastolic diameter, left ventricular ejection fraction in patients with chronic heart failure[J];中国实用医药;2012-34
5 WANG Ye-Feng,HUANG Xi-Yong.Department of Cardiology,Hunan Children's Hospital,Changsha 410007,China;Research advance of brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis and treatment of pediatric cardiovascular diseases[J];中国当代儿科杂志;2012-06
6 ZHANG Zhong-ling1,MAO Jing-yuan2 1Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2Department of Cardiology,the First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193,China;Research Advances in B-type Natriuretic Peptide and Its Clinical Application in the Patients with Cardiovascular Diseases[J];中国医学科学院学报;2012-02
7 WANG Deguo1 WANG Xing1 WANG Xin1 CHEN Yueyun1 CAO Kejiang2(1Department of Gerontology,Yijishan Hospital of Wannan Medical College,Wuhu,Anhui,241001,China;2Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University);Impact of recombinant human B-type natriuretic peptide on autonomic nervous function in patients with moderate and severe heart failure[J];临床心血管病杂志;2012-04
8 WU Yan,PU Hong(Department of Cardiology,the 85th Hospital of PLA,Shanghai 200052,China);Short-term efficacy of recombinant human brain natriuretic peptide in the treatment of acute heart failure in ischemic cardiomyopathy patients[J];世界临床药物;2012-04
9 CHEN Xinjun,ZHEN Ruolong,QIAN Huidong,et al. Department of Cardiology,Affiliated Jiangyin Hospital,College of Medicine,Southeast University,Jiangyin 214400, CHINA;Efficacy of lyophilized recombinant human brain natriuretic peptide in treating acute heart failure induced by acute myocardial infraction or dilated cardiomyomyopathy[J];江苏医药;2012-06
10 YUAN Fang,LIU Hua,ZHANG Min,FANG Weiyi.Department of Cardiology,Shanghai Chest Hospital,Shanghai Jiaotong University,Shanghai 200030,China;Effect of recombinant human B-type natriuretic peptide on heart and renal function in acute decompensated heart failure patients with acute kidney injury[J];上海医学;2011-12
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