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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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The role of metoprolol on cardiac sympathetic signal transduction in a stressed rabbit model

PAN Yu;LIU Ming ming;GUO Shuai;GU Xingbo;YIN Dechun;Department of Cardiology,First Affiliated Hospital of Harbin Medical University Qunli District;  
Objective To investigate the effects of metoprolo]on β-AR-AC-cAMP pathway and ventricular stability in stressed rabbit model.Methods Thirty male rabbits were randomly divided into control group(n=10),stressed group(n = 10),stressed plus ineloprolol treatment group(n= 10).Complex stimulations of sound and electricity for 24 hours were used to establish acute stressed model.To detect ventricular fibrillation induce rate in each group,we measured the serum epinephrine(E),norepinephrine(NE) in the rabbit serum and evaluated the myocardial β-adrenergic receptor(β-AR)density,adenylate cyclase(AC) activity and cyclic adenosine monophosphate(cAMP) levels in ventricular tissues.Results Ventricular fibrillation induce rate in stressed group was significantly higher than control group(x~2 =6.270.P =0.012),the induce rale in treatment group was lower than stressed group(x~2 =9.600,P =0.002),but there was no difference between and treatment group control group(x~2 =0.457,P =0.499).Serum E,NE were higher in stressed group compared to control group(q = 22.49,P 0.01;q = 33.64,P 0.01),and were lower in treatment group compared to stressed group(q =6.45,P 0.01;q =9.76,P 0.01).Ventricular AC activity and cAMP were higher in stressed group compared to control group(q =34.70,P 0.01;q = 11.74,p 0.01),and were lower in treatment group compared to stressed group(q =21.61,P 0.01;q =4.52,p =0.004).Ventricular β-AR density was significantly higher in stressed group compared to control group(q =8.36,p 0.01),but no significant differences were found between treatment group and stressed group(q = 2.21,p =0.129).Equilibrium dissociation constants(KD values) are also appealed no significant difference among these three groups(F =1.096,P =0.349).Conclusion By inhibiting the B-AR-AC-cAMP signal transduction pathway and inhibiting the sympathetic excitation,decreasing of NE and E release,and improve the stability of the ventricle.
【Fund】: 黑龙江省青年科学基金资助项目(QC2015115);; 黑龙江省卫生厅科研课题(2013-015)
【CateGory Index】: R54
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