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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Changes of TSH,FT_3,FT_4,TPOAb and TGAb in patients with hypothyroidism treatment with levothyroxine and selenium supplement

SUN Jingru;HAN Mei;WANG Lu;SUN Wenwen;Department of Thoracic Surgery,Hebei Chest Hospital;Department of Endocrinology,Laoning Jinqiu Hospital;  
Objective To observe the clinical results and changes in TSH,FT_3,FT_4,TPOAb and TGAb of patients with hypothyroidism in treatment with levothyroxine and selenium supplement.Methods Ninety-two cases of patients with hypothyroidism were selected,which were treated in hospital from March 2015 to March 2016,and they were divided into the observation group(46 cases) and control group(46 cases).The patients of control group were treated with levothyroxine tablets(an initial dose of 25 μg,1 time / d,dose adjustment after two weeks of continuous treatment,increasing 25μg each time,until the optimum effect).On the basis of control group,the patients of observation group were treated with selenium yeast tablets(50 μg,orally,2 times / d).The patients of two groups were all treated for 6months.Compare the clinical efficacy and changes of the levels of free three triiodothyronine(FT_3),free four triiodothyronine(FT_4),thyroid stimulating hormone(TSH),thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),high density lipoprotein protein(HDL-C),low density lipoprotein(LDL-C),total cholesterol(TC),triglyceride(TG) of two groups.Results After the appropriate treatment,the patients of the observation group got a total effective rate of 95.7%,which was significantly better than the 82.6%of the control group(x~2 =4.039,P =0.044);In the terms of TSH,TPOAb,TGAb,LDL-C,TC and TG,the patients of two groups were all significantly decreased than before(observation group:t =45.159,t =6.243,t =9.266,t =17.969,t =17.146,t =17.669,control group;t =44.144,t =3.971,t =7.168,t =12.415,t =9.402,t =10.621.P 0.05),and the patients of the observation group got more significant decline(t = 1.896,t =2.685,t =2.061,t =7.058,t=10.636,t=8.724,P0.05);In the terms of FT_3,the patients of two groups were all significantly increased than before(observation group:t=14.524,t=7.673,control group:t=12.723,t=5.903,P0.05),and in the terms of FT_3,the patients of the observation group got more significant increase(t=2.151,P0.05);there were headache,gastrointestinal discomfort,chest tightness,tachycardia,allergic reactions and other adverse reactions occurred in both two groups,but there were no statistically significant between the two groups(X~2=1.170,X~2=0.474,X~2=0.000,X~2=1.593,X~2=2.224,P 0.05).Conclusion With treating patients with hypothyroidism,levothyroxine and selenium supplement can significantly improve the clinical efficacy,effectively improve the levels of thyroid and autoantibodies,and it is also safe and reliable,which makes it worthy of promotion.
【CateGory Index】: R581.2
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 WANG Ruiling;ZHU Hongfang;ZHANG Hui;Department of Obstetrics and Gynecology,Wuchang Hospital of Wuhan City;;The impact of levothyroxine sodium tablets in the treatment of hypothyroidism during pregnancy on the thyroid function and the outcome of the pregnancy[J];疑难病杂志;2016-04
2 LIU Yun;CHEN Yuanyuan;ZHANG Xiyi;LI Weiling;Department of Obstetrics and Gynecology,Xi'an High-tech Hospital;;Safety and effect of levothyroxine sodium tablets in the treatment of pregnancy complicated with hypothyroidism on the pregnancy outcome[J];疑难病杂志;2016-04
3 He Yiping;He Tongqiang;Wang Yanxia;Xu Zhao;Xu Yehong;Wu Yiqing;Ji Jing;Mi Yang;Department of Obstetrics,Child and Maternity Health Hospital of Shannxi Province;;Comparison of the effect of different diagnostic criteria of subclinical hypothyroidism and positive TPO-Ab on pregnancy outcomes[J];中华妇产科杂志;2014-11
4 Lv Fei-juan,Yang Yan-ling,Xu Jing-sheng,Zhu Hua-jun(Department of Endocrinology,PLA 113rd Hospital,Ningbo Zhejiang 315040,China);Clinical observation of treating autoimmune thyroiditis with Sodium selenite[J];临床军医杂志;2013-01
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 SUN Jingru;HAN Mei;WANG Lu;SUN Wenwen;Department of Thoracic Surgery,Hebei Chest Hospital;Department of Endocrinology,Laoning Jinqiu Hospital;;Changes of TSH,FT_3,FT_4,TPOAb and TGAb in patients with hypothyroidism treatment with levothyroxine and selenium supplement[J];疑难病杂志;2017-01
2 WANG Hai-dong;L Shu-yan;Department of Obstetrics,the First Affiliated Hospital of Nanjing Medical University;;Analysis of different TSH criteria for the diagnosis of early pregnancy of subclinical hypothyroidism and the effect of TPO-Ab positive on pregnancy[J];现代医学;2016-12
3 YANG Lu;XU Jing-jing;YANG Lin-dong;ZHAO Hao-yun;WU Yuan-zhe;Department of Gynaecology and Obstetrics, Nanjing General Hospital;;The correlation between hypertensive disorders of pregnancy and thyroid dysfunction[J];中国医学前沿杂志(电子版);2016-11
4 LIU Lu;HONG Zhong-xin;Beijing Friendship Hospital,Capital Medical University;;Influence of subclinical hypothyroidism and positive thyroid peroxidase antibody on pregnancy outcomes[J];中国妇幼健康研究;2016-09
5 Wang Changhong;Zhou Yingying;Wan Yang;Prenatal Diagnosis Center,The First Affiliated Hospital of Anhui Medical University;Fuyang People's Hospital;;Study of two different criteria and screening strategies for subclinical hypothyroidism in pregnant women in Fuyang Area[J];现代妇产科进展;2016-08
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【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 XIA Jun;CHEN Xi;JIN Bai;Department of Endocrinology,Affiliated Shengze Hospital,Nanjing Medical University;;Effects of iodine supplementation on thyroid function of pregnant women with hypothyroxinemia in middle-late pregnancy[J];江苏医药;2015-17
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