Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2017-01
Add to Favorite Get Latest Update

CGRP and SP expression of colorectal mucosa in patients with irritable bowel syndrome and its correlation with clinical symptoms

FANG Liang;ZHANG Fanyong;WU Jixiong;Department of Gastroenterology,Huanggang Central Hospital;  
Objective To investigate the expression of calcitonin gene-related peplide(CGRP) and substance P(SP)in colorectal mucosa in patients with different types of IBS,and the correlation between SP and CGRP and clinical symptoms of IBS.Methods 63 cases of IBS in our hospital from 2012 to 2014 in the Department of digestive medicine were selected,Constipation type IBS 24 cases,diarrhea type IBS 21 cases,mixed type IBS 18 cases,10 cases of colon polyps were selected as the control group.Immunohistochemistry was used to detect the expression of CGRP and SP in colorectal mucosa.Results Granular SP staining was found in the cell membrane,abundant in the cytoplasm of gland cells.The gland around Brown granular glands SP,individual cell membrane Brown granular SP.CGRP immunoreactive nerve fibers were brownish yellow granular,round,oval or irregular shape,aggregation or scattered in the mucosal glands,CGRP expression of IBS group was significantly increased.Diarrhea predominanl IBS patients CGRP expression was significantly higher than that of the constipation predominant IBS,mixed type of irritable bowel syndrome(IBS) and control group(P 0.01) in the ileocecal valve and sigmoid colon;Diarrhea predominanl IBS patients SP expression was significantly higher than that ol the conslipalion predominanl IBS,mixed type of irritable bowel syndrome(IBS) and control group(F_(CGRP)= 2 1.64,3.41,F_(SP) = 5.26,5.41,all P 0.01) in the ileocecal valve and sigmoid colon;CGRP,SP high expression group in defecation difficulty,abdominal pain,stool character were statistically significant difference from low expression group,moderate expression group(F_(CGRP) =3.85,31.76,13.929,F_(SP) =3.450.28.070.9.287,P 0.05).CGRP were positively correlated with abdominal pain,bowel movemem lrails(r =0.999.r =0.999.P 0.05),and negatively correlated with defecation difficulties(r =-0.993.P 0.05);SP were positively correlated with abdominal pain,defecate lrails(r =0.997,r =0.984,P 0.05),and negatively correlated with difficult defecation(r =0.940,P 0.05),stool frequency(r =-0.997,P 0.05).Conclusion The expression of CGRP and SP was significantly increased in patients with diarrhea type IBS,SP and CGRP can affect the defecation difficulties,abdominal pain and stool characteristics and other symptoms.
【CateGory Index】: R574
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 LUO Sha;WU Min;FANG Yu;CHEN Shan;Nanning City TCM Hospital in Guangxi;;Thirty Cases of Irritable Bowel Syndrome Treated with Aromatic Moxibustion in Combination with Psychological Counseling[J];河南中医;2018-07
2 ZHENG SU;XU Jing;PENG Li;Taihe Hospital,Affiliated Hospital of Hubei University of Medicine;;Electro-Needling ST36 in IBS Rats:Study on Gastrointestinal Function,CGRP,SP and VIP[J];针灸临床杂志;2018-03
3 ZHI Jiaxi;SHI Hanyan;XU Xiaorong;WU Yahui;WU Chengming;Shanghai Tongji University School of Medicine;;Effect of trimebutine maleate in treatment of irritable bowel syndrome and its effect on inflammatory mediators[J];疑难病杂志;2017-04
【Citations】
Chinese Journal Full-text Database 4 Hits
1 ZHANG Ya-nan;ZHAO Hai-jun;WANG Yuan;LU Yan;WANG Shi-jun;College of Basic Medical Science,Shandong University of Traditional Chinese Medicine;College of Acu-moxibustion and Tuina,Shandong University of Traditional Chinese Medicine;International Education College,Shandong University of Traditional Chinese Medicine;;Effect of Electroacupuncture Intervention on Constipation-predominant Irritable Bowel Syndrome and Colonic CGRP and SP Expression in Rats[J];针刺研究;2016-01
2 LUO He-sheng;LIANG Wen-jing;LIANG Lie-xin;ZHANG Guo;ZHANG Fa-can;Department of Gastroenterology,Renmin Hospital,Wuhan University;Department of Gastroenterology,the People's Hospital of Guangxi Zhuang Autonomous Region;;Relationship between expression of CGRP/SP and clinical symptoms in irritable bowel syndrome[J];临床消化病杂志;2014-06
3 ZHANG Yanan;WANG Shijun;School of Basic Medicine,Shandong University of TCM;School of International Education,Shandong University of TCM;;Effects of electro-acupuncture on CGRP,SP mRNA expression of colon tissues of rats with constipation-predominant irritable bowel syndrome[J];吉林中医药;2014-09
4 @ZHANG Ya-nan$International eucation clleage of Shandong uiversity of taditional Chinese mdicine!Jinan 250355,China @WANG Shi-jun @WANG Xiao-yan$International eucation clleage of Shandong uiversity of taditional Chinese mdicine!Jinan 250355,China;Effects of electroacupuncture on plasma CGRP and SP expression in rats of constipation-predominant irritable bowel syndrome[J];国际中医中药杂志;2013-05
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 PEI Li-xia;ZHANG Wei;SONG Ya-fang;GENG Hao;CHEN Lu;WU Xiao-liang;ZHOU Jun-ling;SUN Jian-hua;Jiangsu Provincial Hospital of Traditional Chinese Medicine;The Second Clinical College of Nanjing University of Traditional Chinese Medicine;;Electroacupuncture of “Tianshu”(ST 25) Suppresses Visceral Pain Possibly by Down-regulating Mast Cell Activation,and Tryptase and SP Expression in Rats with Post-infectious Irritable Bowel Syndrome[J];针刺研究;2018-07
2 MU Xin;ZHANG Zhiling;WANG Ruini;CHUN Lixia;LIU Yun;Department of Dermatology,the First Affiliated Hospital of Xi'an Jiaotong University;Department of Dermatology,Baoji Second Traditional Chinese Medicine Hospital;;Efficacy of Betamethasone Combined with Plum-blossom Needle for Alopecia Areata and Their Effects on Plasma Substance P[J];中国皮肤性病学杂志;2018-03
3 DU Pengli;ZHAO Danyang;GU Nuonuo;YANG Qian;Graduate School of Hebei Medical University;;Experience of YANG Qian in Treating Constipation-Predominant Irritable Bowel Syndrome with Mazhi Jiangzhuo Formula[J];山东中医杂志;2018-02
4 LI Yimeng;Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;;Evolution of TCM experimental animal model of irritable bowel syndrome and modeling assumption[J];上海中医药杂志;2017-S1
5 Bu Xiumei;Wang Wengang;Liaoning University of Traditional Chinese Medicine;Central Hospital Affiliate to Shenyang Medical College;;Effect of Modified Liumo Decoction on Serum Neuropeptide Y,Substance P and 5-HT Levels in Patients with Constipation Predominant Irritable Bowel Syndrome[J];中国药业;2017-23
6 LEI Cheng-cheng;LI Liang;ZHANG Hong;LI Jia;ZHANG Qing;LIU Shi-qin;TIAN Ye-ye;TIAN Hao;YU Ling-ling;Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology;College of Acupuncture-moxibustion and Orthopedics-traumtology,Hubei University of Chinese Medicine;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences;;Effect of Electroacupuncture Stimulation of Sensitized Acupoints on Bowel Dysfunction in Rats with Diarrhea-predominant Irritable Bowel Syndrome[J];针刺研究;2017-05
7 TAN Li-hua;LI Kai-ge;WU Yan-ying;LAN Ying;GUO Meng-wei;ZHU Wen-lian;ZHANG Lu-fen;ZHAO Ya-fang;LI Xiao-hong;REN Xiao-xuan;School of Acu-moxibustion and Tuina,Beijing University of Chinese Medicine;;Effect of Electroacupuncture at “Yintang” (GV 29) and “Tianshu” (ST 25) on the Ethology and the Expression of TRPV 1 Receptor in Colon of Irritable Bowel Syndrome Rats[J];针刺研究;2017-02
【Co-references】
Chinese Journal Full-text Database 7 Hits
1 WU Yanying;REN Xiaoxuan;GUO Mengwei;TAN Lihua;LI Kaige;LAN Ying;WANG Shan;JI Maoxian;ZHANG Honglin;Beijing University of Chinese Medicine;;Comparing effects of ST36 and LI14 on intestinal pain sensitivity and abnormal motility in IBS rat[J];北京中医药大学学报;2017-06
2 ZENG Ming-xi;KANG Chang-ming;CHEN Xiao-hong;The People's Hospital of Shichuan Province;;Study on the Relationship the Expression of Interleukin and Tumor Necrosis Factor with Irritable Bowel Syndrome[J];医学临床研究;2017-05
3 ZHANG Hui;MIAO Qi;WU Yuelong;WAN Jian;WANG Shanjuan;LU Fang;LIN Yonghui;REN Haifeng;LI Xiaobo;Department of Gastroenterology,Shanghai Jiading District Central Hospital;Division of Gastroenterology and Hepatology,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine;Department of Pathology,Shanghai Jiading District Central Hospital;;Effect of Mesalazine Combined with Trimebutine on Mast Cell and Related Inflammatory Mediators in Colonic Mucosa in Patients with Irritable Bowel Syndrome[J];胃肠病学;2017-05
4 FANG Liang;ZHANG Fanyong;WU Jixiong;Department of Gastroenterology,Huanggang Central Hospital;;CGRP and SP expression of colorectal mucosa in patients with irritable bowel syndrome and its correlation with clinical symptoms[J];疑难病杂志;2017-01
5 Wang Yan;Liu Xin;Huang Xiaoping;Li Yong;Luo Jinyan;Department of Gastroenterology,Second Affiliated Hospital of Xi'an Jiaotong University;;Expression of inflammatory cytokines and its correlation with peptide YY and claudin-1 in patients with irritable bowel syndrome[J];中华消化杂志;2016-12
6 Feng Zehui;Gong Yun;Lan Hongmin;Meng Yongxian;Department of Gastrointestinal Surgery,Dongfeng Hospital Affiliated to Hubei University of Medicine,Hubei Province;Department of Oncology,Dongfeng Hospital Affiliated to Hubei University of Medicine,Hubei Province;Department of Otorhinolaryngology,Dongfeng Hospital Affiliated to Hubei University of Medicine,Hubei Province;Department of Supply Room,Dongfeng Hospital Affiliated to Hubei University of Medicine,Hubei Province;;Application value of quality control circle in irritable bowel syndrome patients with nutritional support in emergency[J];中国医药;2016-12
7 ZHAO Ju-hui;DONG Lei;WANG Zong-yan;Department of Gastroenterology,the Second Affiliated Hospital of Xi'an Jiaotong University;Shaanxi Key Laboratory of Gastrointestinal Motility Disorders;Shaanxi Clinical Research Center of Gastrointestinal Diseases;;The role of protease activated receptor 2 in visceral sensitivity of irritable bowel syndrome patients[J];西安交通大学学报(医学版);2017-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Yanan;WANG Shijun;School of Basic Medicine,Shandong University of TCM;School of International Education,Shandong University of TCM;;Effects of electro-acupuncture on CGRP,SP mRNA expression of colon tissues of rats with constipation-predominant irritable bowel syndrome[J];吉林中医药;2014-09
2 DENG Xue;REN Lu;LI Jing;SUN Jian-duan;FU Shen-kang;ZHAO Shou-zhang;College of Acu-moxibustion and Massage,Liaoning University of Traditional Chinese Medicine;;Effect of Electroacupuncture Stimulation of “Ganshu”(BL 18) on Locomotor,Gastric Mucosal and Hypothalamic SP Immunoactivity and Hippocampal 5-HT Content in Rats with Depression and Gastric Ulcer[J];针刺研究;2014-02
3 LI Ningning,FANG Xiucai Department of Gastroenterology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China;Role of the brain-gut axis in pathogenesis of irritable bowel syndrome[J];胃肠病学和肝病学杂志;2013-02
4 Tao Huo,Tuan-Min Hu,Si-Fu Huang,Department of Gastroenterology,the 180th Hospital of Chinese PLA,Quanzhou 362000,Fujian Province,China;Effect of Huangshu Enema on mast cells and substance P in rats with diarrhea-predominant irritable bowel syndrome[J];世界华人消化杂志;2012-03
5 WANG Yan-jie,GUAN Hong-quan,CHAI Ji-yan,ZHAO Jin-ru,LIU Hui-hui,HAN Xiao-wei,LIU Xu-dong,WANG De-shan(School of Basic Medicine,Liaoning University of TCM,Shenyang 110032,China);Effects of eye-acupuncture therapy on expression of SP rats with irritable bowel syndrome[J];中华中医药杂志;2011-10
6 YAN Xiujuan,CHEN Shengliang.Department of Gastroenterology,Renji Hospital,Shanghai Jiaotong University School of Medicine Shanghai Institute of Digestive Disease,Shanghai(200001);Research Progress of Mucosal Mast Cells in Mechanism of Visceral Hypersensitivity in Postinfectious Irritable Bowel Syndrome[J];胃肠病学;2011-07
7 HAN Guang-yan1,SUN Jian-hua2(1.Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China;2.Jiangsu Province Hospital of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China);Acupoint Selection Rules of Acupuncture Therapies for Irritable Bowel Syndrome:Preliminary Exploration[J];辽宁中医药大学学报;2011-05
8 SONG Shi-yi,WANG Yan-jie,WANG De-shan,CHAI Ji-yan(College of Basic Medicine,Liaoning University of Chinese Medicine,Shenyang 110032,China);Effects of Oculo-acupuncture Therapy on Colonic Serotonin Reuptake Transporter Expression in Rats with Irritable Bowel Syndrome[J];针刺研究;2011-02
9 QI Li1,LI Na1,LIU Hui-rong2,MA Xiao-peng2,WU Lu-yi1,WANG Xiao-mei2,ZHOU Ci-li2,WU Huan-gan2 (1Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;2Shanghai Research Institute of Acupuncture and Meridian,Shanghai 200030,China);Clinical and experimental studies on moxibustion for treatment of irritable bowel syndrome[J];中华中医药杂志;2010-12
10 ZHANG Junjun, XIONG Huiling,CHU Dan,CHENG Pengfei,QIAN Wei,LIU Shi. Department of Gastroenterology,Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan (430022);Effect and Mechanism of Electroacupuncture at ST-36 on Visceral Hypersensitivity in Rats[J];胃肠病学;2010-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved