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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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A study of the concentration of haptoglobin in serum before and after Huashixingyuqingre decoction in treatment of oral lichen planus

GUO Feng;ZHANG Meijie;XU Yanzhi;LIU Fengying;LIU Shanshan;CHEN Si;DUAN Yanhao;YAO Manman;Department of Stomatology,First Clinic of Hebei Province;  
Objective To observe the therapeutic effect of self-made Huashixingyuqingre decoction(HXQD) on oral lichen planus(OLP),and the effect on the serum haptoglobin concentration and the level of peripheral blood T lymphocyte subsets.Methods From October 2013 to May 2015,42 OLP patients were collected from Department of Stomatology,the fourth hospital of Hebei Medical Liniversity and the first outpatient department of directly departments of Hehei Province.The subjects were divided into 2 groups,treatment group and control group,each group having 21 individuals.Roth groups were given conventional treatment,the basal parts of oral lesions in control group were sealed by cod liver oil topical application and triamcinolone acetonaide acetate injection,while treatment group were given Huashixingyuqingre decoction.The serum haptoglobin concentration and the changes of peripheral blood T lymphocyte subsets before and after treatment were detected,and curative effects of two groups were compared.Results The total effective rate of treatment group was 90.5%,which was significantly higher than the control group's 61.9%(x~2 =4.725,P 0.05);After 8 weeks of treatment,the serum Hp concentration of the treatment group was higher than that before treatment(t =3.933,P 0.01).which higher than that in the control group as well(t =2.247.P 0.05).After 8 weeks of treatment,peripheral blood CD3~+,CD4~+ in two groups were not only higher than before treatment(P 0.01),but also higher than the control group(t =5.170,t =4.402,P 0.01).Although peripheral blood CDS~+ and CD4~+ /CD8~+ were higher than before treatment,the difference was not statistically significant(P 0.05).Conclusions The HXQD has a certain curative effect on oral lichen planus,the serum haptoglobin concentration and changes oi peripheral blood T lymph subsets,it mav have some effect on the occurrence and development of oral lichen planus as well.
【Fund】: 国家自然科学基金资助项目(81273813)
【CateGory Index】: R276.8
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