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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Association between MDM2-309T/G polymorphism and esophageal carcinoma susceptibility:A Meta-analysis

WANG Qian;TAN Shiyun;WU Pengbo;LIU Jian;Department of Gastroenterology,Renmin Hospital of Wuhan University;  
Objective To explore the association between the MDVI2-309T/G polymorphism and Esophageal carcinoma susceptibility.Methods Data bases were comprehensively searched to retrace all the related studies on the associations between MDM2 polymorphism and esophageal carcinoma susceplibility in population.The pooled odds ratios(ORs) with 95%confidence intervals(95%(ds) of the association between MDM2 polymorphism and esophageal carcinoma susceptibility were performed in different genetic model comparison.Publication bias was detected by symmetry of funnel plot.Results Seven original studies with a total of 5 533 subjects(2 206 patients and 3 327 controls) were entered the final data combination.The results of Meta-analyses showed that the variant homozygote(309G/G genotype) and the variant heterozygole(309T/G genotype) were significantly associated with an increased risk of esophageal carcinoma as compared to wild type homozygote(309G/G genotype;OR =11.64,95%CI 10.17 to 13.31;309T/G genotype:OR =11.07.95%CI 10.02 to 12.22).A significantly increased risk of esophageal carcinoma was observed lor the recessive model(GG vs.TT/TG;OR =1.17,95%CI 1.03 to 1.32).While in the dominant model(GG/TG vs.TT),non-significant association was observed(OR = 1.02,95%CIO.94 to 1.11).In the subgroup analysis by ethnicity,mela-analvsis strongly suggests thai there are significant associations between MDM2 309T/G polymorphism and esophageal carcinoid susceptibility in Chinese[GGvs.IT:OR = 10.77,95%CI9.35,12.42,P =0.000;GT vs.TT:OR =10.11,95%GI9.11,11.23,P =0.000;GG vs.GT/TT:OR =7.03,95%676.44,7.67.P =0.000;GG/GT vs.TT:OR =5.86,95%CIS.12,6.69,P =0.000].Conclusion The MDM2-309 GG may contribute to esophageal carcinoma in Chinese population.
【CateGory Index】: R735.1
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