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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Clinical research for the treatment of given immune enteral nutrition by the jejunum nutrition tube on the patients with severe acute pancreatitis

LIU Bo;WANG Yumei;HUO Shuang;ZHOU Shaoying;XU Shuai;WANG Xiaoli;YAN Tingqi;Department of Emergency,the Handan Central Hospital;  
Objective To investigate the effect of enteral nutrition support in the treatment of severe acute pancreatitis with nutritional index,immune index and inflammatory response index.Methods We collected 72 patients with severe acute pancreatitis from January 2013 to December 2015.They were randomly divided into research group and control group,each group had 36 cases.All patients were treated with conventional treatment,research group were received immune enteral nutrition therapy by jejunum nutrition tube,control group were received parenteral nutrition support.Compare two groups after treatment,patients' nutrition indicators(Alb,PAB),humoral immunity(IgA,IgG,IgM),cellular immunity(TLC,CD3~+,CD4~+) and inflammatory indicators(CRP,TNF-α,IL-6) changes.Results Two groups of patients given different nutrition after treatment,the indicators were obviously improved.At 7 days and 14 days,the ALB and PAB levels of the research group were significantly higher than that of the control group(t_7= 1.717,t_7=2.957;t_(14) =2.411,t_(14) = 2.182,P 0.05);Treatment for 14 days,the IgA,IgC,IgM,TLC,CD3~+,CD4~+ of the research group were improved significantly better than the control group(t =2.031,t =2.106,t =2.198,t = 2.050,t =2.182,1 = 1.850,P 0.05).At the same lime,the CRP,TNF-α,IL-6 of the research group declined significantlv than the control group(t =2.437,t = 1.705,t =2.697,P 0.05).Conclusion The jejunum nutrition tube given immune enteral nutrition in treatment of severe acute pancreatitis can effective!) improve the nutritional status and immune function of patients,reduce the inflammatory reaction in patients with acute reaction period,so as to improve the prognosis and improve the clinical efficacy.
【CateGory Index】: R576
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