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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Research progress of Tbx18 in biological pacemaker

ZOU Qiang;HUANG Congxin;Department of Cardiology,Renmin Hospital of Wuhan University;  
Since its introduction into clinical practice,electronic pacing has saved many lives.Despite continuous improvements,electronic pacemakers have important shortcomings,which stimulated the development of biological alternatives.Over the past decade,significant improvements have been made in biological pacemakers,human embryonic transcription factor Tbx18 can directly convert ordinary ventricular carcliomyocvles into pacemaker cells and has made remarkable achievements,but issues remain ill relation to long term outcomes and salety.Whether biologicals will ultimately supplement or supplant electronics remains to be seen.This paper reviews the research progress of Tbx18 in biological initiation.
【Fund】: 中央高校基本科研业务费专项资金(2042015kf0229 2042014kf0306)
【CateGory Index】: R541.7
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