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《Chinese Journal of Difficult and Complicated Cases》 2017-01
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Research progress on the relationship between hemopexin and cardiovascular diseases

SU Jiyuan;LI Qiheng;HE Zhiqing;LIANG Chun;WU Zonggui;Department of Cardiology,Changzheng Hospital,Second Military Medical University;  
Hemopexin(Hx) as an acute phase plasma glycoprotein mainly expressing in liver,had been proven to show high binding affinity with free heme and play key roles of eliminating overloading free heme from circulation.Such process had been done to alleviate oxidative stress and tissue injuries In binding with free heme and then transferring into cells\ia specific receptors for degradation.Data from previous studies showed that abnormal Hx levels existed in the setting of several diseases.Nowadays,great progress bad been made in such topic concerning about IK and showed potential implementation in the treatment ol cardiovascular related diseases,such as atherosclerosis,cerebral ischemic injury,and multiple sclerosis el al.Strategies aiming at Hx were confirmed to improve the prognosis of the animal models with the above diseases.So such progress about the modulation of cardiovascular related diseases by Hx was summarized in this review.
【Fund】: 国家自然科学基金重点项目(81130065) 国家自然科学基金面上项目(81270405 81473445)
【CateGory Index】: R54
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