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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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The influence of RICP on levels of apelin in obesity AMI patients following PCI treatment

BU Lun;ZHU Hailong;YUAN Jian;LIU Chaoying;DING Zhongru;Department of Cardiology,The 309th Hospital of Chinese People Liberation Army;  
Objective To observe the effect of remote ischemic adaptation(RIPC) on the level of serum vislatin(Apelin) in patients with acute myocardial infarction(AMI) after percutaneous coronary intervention(PCI).Methods Forty eight obesity AMI patients from June 2013 to June 2014 were enrolled in the 309 th Hospital of Chinese People Liberation Army and they were divided into two groups equally and randomly:RIPC group and non RIPC group.All the AMI patients were received PCI treatment.The levels of apelin,NT-proBNP and cTnI were measured before PCI and one week after PCI.All the patients were following a 2 years investigation for MACE rate.Results The contents of apelin[(61.4 ± 1 1.2) ng/ml vs.(33.7 ±6.5) ng/ml,t=2.760,P =0.005]and cTnl[(77.1 ±8.6)ng/ml vs.(4.2±1.1) ng/ml,t=2.632,P =0.006]in RICP group were significantly decreased one week after PCI treatment.However,the levels of apelin[(62.7 ±9.6) ng/ml vs.(79.3 ±14.1) ng/ml,t =2.127,P = 0.021]and NT-proBNP[(357.6 ±31.5) pg/ml vs.(412.3±72.8) pg/ml,t =1.992,P =0.027]were increased after PCI in non RIPC group,Correlation analysis showed that RIPC was negatively related with Aapelin(r =- 0.698,P 0.05) and MACK(r =- 0.611,P 0.05).MACE was negatively associated with Aapelin(r =-0.653,P 0.05).Conclusion RIPC can improve long term outcome in obesity patients with AMI by regulating serum levels of apelin.
【CateGory Index】: R542.22
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