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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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Relationship between N-terminal pro brain natriuretic peptide in patients with acute cerebral infarction and carotid artery intima media thickness

WANG Guanghui;FENG Min;XU Yuanyuan;ZHU Fangfang;Department of Neurology,the Second Affiliated Hospital of Bengbu Medical College;  
Objective To analyse acute cerebral infarction(ACI) patients plasma NT-proBNP and the change of area,and different infarction location,carotid atherosclerosis(CAA) and the correlation between the degree of neural function defect and prognosis.Methods Ninety cases of patients with acute cerebral infarction from February 2015 to September 2016 in the Second Affiliated Hospital of Bengbu Medical College Department of Neurology enrolled as the case group,40 cases of healthy volunteers were taken as control group.To test and compare the infarction group admitted 24 h,7 d,14 d for treatment and the healthy control group.Plasma NT-proBNP levels,according to the head MR examination results of the area and position of infarction,were compared at 24 h,7d,14 d,after treatment;used color Doppler ultrasonic to detect 2 groups of carotid artery intima media thickness(IMT),and the correlation analysis was performed with NT-proBNP 24 h plasma level of admission;the National Institutes of Health Stroke Scale(NIHSS) were used to group the degree of nerve function defect infarction,and the correlation analysis was performed with NT-proBNP 24 h plasma level.Results The NT-proBNP level in plasma of patients with infarction group were significantly higher than the control group(t=16.840,P=0.00),NT-proBNP24 h plasma level were the highest,then gradually decreased at 2 weeks minimum;severe sub group admission 24 h plasma NT-proBNP level was significantly higher than the mild group,mild sub group higher than healthy group(F=102.386,P=0.00),and the prognosis was gradually improved;large area cerebral infarction sub group admitted 24 h,seventh days,fourteenth days of plasma NT-proBNP level was significantly higher than that in the area of cerebral infarction subgroup,NT subgroup in the plasma level of proBNP was significantly higher than that of small area cerebral infarction area cerebral infarction subgroup(F=188.694,F =200.641,F =181.731,P =0.00) before and after;cerebral infarction plasma NT-proBNP levels showed no significant difference(F =0.000,P 0.05);the 2 groups were statistically significant differences in carotid artery IMT(t = 14.901,P =0.00),and the infarction group's level of NT-proBNP in plasma of patients with 24 h was positively correlated with NIHSS and IMT(r =0.692,r =0.672,P =0.00).Conclusion Acute cerebral infarction in patients with acute phase plasma NT-proBNP levels were significantly increased and the infarct size was positively correlated with the infarction site,is a risk factor for carotid atherosclerosis,can be used to assess the severity of cerebral infarction patients and prognosis.
【CateGory Index】: R743.33
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