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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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Clinical significance of serum levels of omentin and adiponectin in patients with viral hepatitis B cirrhosis

WEI Xinliang;WEI Sichen;TIAN Shuying;KONG Yu;WANG Weiwei;JIANG Hongyu;Second Department of Gastroenterology,Cangzhou Central Hospital,Hebei Province;  
Objective To determine the level of serum omentin and adipouectin in patients with viral hepatitis B cirrhosis,and to analyze the relationship between the levels of insulin,Child-Pugh,liver biochemical indexes and blood lipids.Methods From March 2014 to March 2015,in Cangzhou Central Hospital of Hebei Province Department of Gastroenterology,67 cases of hepatitis B cirrhosis patients(observation group) were divided as follow;20 cases of Child Pugh grade A,24 eases of grade B,23 cases of grade C,the other 30 cases of healthy people were selected as healthy control group,analysis of the serum omentin,adipouectin and related clinical and biochemical parameters changes.Results Serum omentin and adipouectin levels were significantly higher than the control group(t =3.61,t =6.58,P =0.00).the observation group had no statistical significance in A,B,C 3 levels between omentin and adipouectin level differences(F =0.640,F =0.530,P 0.05),serum adipouectin,visfatin levels and HOMA IB and insulin levels were not significantly correlated(r =-0.027,P=0.864,r =-0.125,P=0.420;r =-0.057.P =0.714,r =0.024,P =0.876),were positively correlated with adiponcctin,and omentin levels of albumin(r =0.406,P =0.007,r =0.351,P =0.020),adiponectin was positively related to HDL-C(r =0.313,P =0.039).The area of BOC curve in serum of patients with hepatitis B cirrhosis was0.768 and,and the cut value of off was about 931.08 ng/L and 809.28 μg/L,respectively.Conclusion The level of serum omentin and adiponectin in patients with liver cirrhosis can be used as an indicator to predict the incidence of hepatitis B cirrhosis.The value of adiponectin is higher,hut it can not be used as an indicator of the severity of liver function.
【Fund】: 河北省沧州市科学技术研究与发展指导计划项目(141302056)
【CateGory Index】: R512.62;R575
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