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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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Relationship between serum FABP4,chemerin,Nesfatin-1 and insulin resistance and beta cell function in patients with gestational diabetes mellitus

SHEN Lifang;SONG Ge;HUANG Qing;PEI Jiong;Department of Endocrinology;the First People's Hospital of Changshou City,Jiangsu Province;  
Objective To analyze the relationship between fatty arid binding protein 4(FABP4),chemokine(chemerin),and dietary inhibitory(actor(Neslatin-1) and insulin resistance and beta cell function in patients with gestational diabetes mellilus(GDM).Methods From June 2013 to October 2015,50 GDM patients(GDM group) admitted to the first people's Hospital of Changshou City of Jiangsu province Department of Endocrinology were enrolled as the research object,the other 40 cases of healthy pregnant women as control group,2 groups of serum FABP4,chemerin,Nesfatin-1 levels and IK and beta cell function index were compared.Results The levels of FAI3P4,chemerin and Neslatin-1 in the GDM group were significantly higher than those in the healthy control group[(35.11 ± 11.32) μg / L vs.(21.14 ±8.75) μg/L,(8.41 ±3.33) mg/L vs.(2.86±0.74) mg/L,(4.99 ± 1.61) μg/L vs.(2.01 ±0.44) μg/L,t =2.559,t =2.224,t =2.112,P =0.008.P =0.017,P =0.021].The levels of HOMA-IR,HUMA-β.1NSAUC / PCAUG and △ 130 /△ G30 in GDM group were lower than those in healthy control group[(2.12 ±0.66) vs.(3.74±1.29),(165.32 ±24.45) vs.(102.27 ±24.12),(10.81 ±3.95) vs.(8.01 ±3.32),(21.51 ±4.98) vs.(15.91 ±6.33).t=2.056,2.840,2.392.2.616,P =0.024,P =0.004,P=0.011,P =0.007].F.ABP4,chemerin and Nesfatin-1 were positively correlated with HOMA-IR(r = 0.422,r =0.379,r =0.345,P 0.05),and negatively correlated with HOMA-13(r =-0.466,r =-0.312,r =-0.326,P 0.05).Conclusion The levels of FABP4,chemerin,Nesfatin-1 were significantly increased in patients with GDM,and there was some correlation between 1R and pancreatic beta cell function.
【CateGory Index】: R714.256
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