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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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The impact of hemorheology of Mailuoshutong particles rivaroxaban to treat of deep venous thrombosis

BAI Dou;JIANG Lanshan;WU Shaohui;ZHANG Xiaojie;ZHENG Jiali;Department of Vascular Surgery,Mianyang Central Hospital,Sichuan Province;  
Objective To explore the impact of clinical efficacy,blood rheology and inflammation of Mailuoshutong particles rivaroxaban in patients with deep venous thrombosis.Methods From June 2014 to June 2016 in Sichuan province Mianyang Central Hospital,120 cases of patients with deep venous thrombosis as the research object were enrolled,according to randomly method,they were divided into observation group(n=60) and control group(n=60).2 groups treated with absolute bed rest,limb elevation,braking,and the control group was given oral treatment of rivaroxaban.In the observation group were given Mailuoshutong particles of 7 d,after treatment,2 groups of patients' clinical curative effect,respectively before and after treatment were observed,and clinical symptoms,blood rheology and serum interleukin 6(IL-6),high sensitive C reactive protein(hs-CRP) were compared.Results The total efficiency of the observation group was significantly higher than the control group(96.67%vs.83.33%,X~2=5.926,P=0.015),but no significant difference in complications(3.33%vs.5.00%,X~2=0.209,P=0.648).After treatment,the observation group pain score,limb circumference,pigmentation score,ulcer area significantly decreased compared to the control group(t=4.865,t=10.263,t=3.034,t=12.474,P=0.000);plasma D dimer(D-D),fibrinogen(FIB),plasma viscosity(CP),erythrocyte aggregation index(RCAI) level significantly decreased compared to the control group(t=21.278,t=22.585,t=3.387,t=8.735,P=0.000);serum IL-6,hs-CRP levels significantly decreased compared to the control group(t=18.320,t=7.241,P=0.000).Conclusion Mailuoshutong particles combined with rivaroxaban can effectively improve the patients with deep venous thrombosis clinical treatment effect,improve clinical symptoms and blood viscosity,and can effectively reduce the inflammatory reaction,is conducive to the prognosis of patients.
【CateGory Index】: R543.6
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