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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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Effect of oxycodone pretreatment in the fracture postoperative analgesia

DENG Xuefeng;ZHU Yanhao;CHANG Qimin;LENG Minghao;CHEN Kang;Department of Anesthesiology,the First Affiliated Hospital of Anhui University of TCM;  
Objective To analyze the effects of oxycodone preconditioning on postoperative analgesia in fracture.Methods From March 2012 to July 2015.in Anhui University of Traditional Chinese medicine,the First Affiliated Hospital,98 cases underwent elective surgery under general anesthesia in Department of orthopedics patients,according to admission order number,they divided into control group and observation group with 49 cases in each group,2 groups were given analgesic treatment,the control group was treated with fenlanyl intervention,observation group used oxycodone hydrochloride injection intervention,2 groups of patients were compared with extubalion(T1),extubalion Smin(T2),exiubation 0.5h(T3) and heart rate(HR),systolic blood pressure(SBP),sedation(Ramsay) score changes,using visual analogue scale(VAS) to assess of postoperative 2 h,4 h,6 h,12 h,24 h,H 2 groups of pain,preoperative,postoperative 24 h patients with inlerleukin 6(IL 6),tumor necrosis factor alpha(TNF alpha) levels,statistical postoperative incidence of adverse events.Results(1) T1,T2 time,2 groups had no statistical significant differences of HR,SBP,Ramsay score(P 0.05),13 SBP.HR of the observation group lower than in the control group,Ramsay score higher than the control group(P 0.05);(2) 2 h alter the operation,the 2 groups' rest of the time points' VAS scores were increased(F =19.304,F =15.227,P =0.000).but different lime points alter surgery of the observation group' s VAS scores were lower than the control group(t =18.783.t =11.649.;=13.590,t =11.200.t =21.913,P =0.000);(3) compared with the same group before operalion,IL 6 and TNF alpha level increased in both of 2 groups 24 h after surgery,the difference was statistically significant(observation group:t =5.840,t=5.079,P 0.05;control group:t = 11.908,t = 11.238,P =0.000),the observation group increased degree significantly lower than the control group(t =6.773,t =8.170,P 0.05);(4) the incidence rate of adverse reaction and complication of the 2 groups showed no differences statistical significance(P 0.05).Conclusion Oxycodone analgesia for pretreatment of orthopedic surgery can reduce postoperative pain,stable hemodynamics,reduce inflammatory reaction,and with high safety.
【CateGory Index】: R614.2
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