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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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Analysis of common causes and risk factors of chronic cough in children:report of 279 cases

WENG Zelin;JIANG Wenwen;ZHENG Yanxia;XU Youjia;Department of Pediatrics,Guangdong Province Traditional Chinese Medical Hospital;  
Objective To sum up the common causes of chronic cough in children,and to explore the risk factors of chronic cough.Methods Two hundred and ninety-five children with chronic cough who treated in Guangdong Province Traditional Chinese Medical Hospital from November 2012 to October 2015 were enrolled,and 16 cases were excluded from the inclusion criteria,the rest of patients with chronic cough were divided into 3 groups according to their age,including the infant group,the preschool group and the school age group.Through the prospective clinical research methods,diagnosis was made according to the diagnostic procedure of chronic cough.Through single factor analysis to determine the difference between the three groups of different causes of the relevant factors,through the multi factor non conditional Logistic regression analysis to explore the risk factors of UACS,CVA and PIC.Results 279 cases of chronic cough etiology:UACS 79 cases(28.31%),CVA 91 cases(32.62%),PIC 90 cases(32.26%),19 cases(6.81%);for sick infants were mainly caused by PIC,the constituent ratio of roughly the same of the 3 factors in preschool group,school- age mainly caused bv CVA.A common cause of chronic cough in the situation analysis showed that sex,tobacco,environmental exposure and 31 factors have significant difference in different etiology group(P 0.05);by multi factor non conditional Logistic regression analysis showed that UACS risk factors include family smoking(tobacco exposure),daytime cough,decubitus cough and nasal obstruction(P 0.05);CVA risk factors include family history of allergic rhinitis,family history of asthma,cold air or odor stimulation,allergens(P 0.05);PIC's risk factors including climate change factors and antibiotic use(P 0.05).Conclusion The etiology of chronic cough was different in different age groups,and the same causes were different in different age groups.The clinical features can provide clues for the diagnosis of chronic cough.UACS risk factors,including family members of smoking(tobacco exposure),cough during the day,the sleeping position,cough,nasal obstruction;CVA risk factors include family history of allergic rhinitis,family history of asthma,cold air or odor stimulation,allergen;PIC risk factors,including climate change factors and the use of antibiotics.
【Fund】: 广东省中医药管理局2013年建设中医药强省科研课题(20132168)
【CateGory Index】: R725.6
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