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《Chinese Journal of Difficult and Complicated Cases》 2017-02
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Research progress of erythrocyte apoptosis in cardiovascular diseases

LI Qiheng;SU Jiyuan;WU Zonggui;Department of Cardiology,Shanghai Changzheng Hospital,Second Military Medical University;  
Erytosis,a programed suicidal death of the red cells,is characterized by erythrocyte shrinkage,blebbing,and phospholipid scrambling of the cell membrane.Behind mechanisms include abnormal increased concentration of intracellular Ca"*,aggravated oxidative stress,excess burden of ceramide and so on.Excessive red blood cell apoptosis was shown to participate in several pathological processes such as microcirculation dysfunction,local thrombosis formation,and anemia worsening.Furthermore studies confirmed key roles of erytosis in the initiation and progress of hypercholesterolemia,cardiac failure,diabetes,renal failure and other diseases.This paper provided the readers a thorough review of trigger mechanisms and the potential association with cardiovascular related diseases.
【Fund】: 国家自然科学基金资助项目(81130065 91539118 81473445)
【CateGory Index】: R54
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