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《Chinese Journal of Difficult and Complicated Cases》 2017-03
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The recent therapeutic effect of thoracoscope surgery in patients with lung cancer and the influence on serum Pentraxin 3,HE4 levels

GUAN Tinghua;JIANG Jianqing;YU Yongkang;MAO Ping;Department of Thoracic Surgery,the Chengdu military Command General Hospital;  
Objective To investigate the short-term efficacy of video-assisted thoracoscope surgery(VATS) in the treatment of patients with non-small cell lung cancer and the effect of serum levels of 3(Pentraxin 3) and human epididymis protein(HE4).Methods 96 cases of patients with lung cancer in our hospital from January 2013 and July 2013 were the diagnosed and treated,48 routine traditional open heart surgery as the control group,48 routine thoracoscope surgery as test group,two groups' of surgery,the recent curative effect,prealbumin(PA) and white blood cell(WBC) levels and pulmonary function[forced expiratory volume in 1 second(FEV_1),per minute ventilation(MV)],Pentraxin 3 and HE4 levels,complications were compared.Results The operation time and lymph node cleaning number of two groups' difference were not statistically significant(t =0.499,t =1.016,P 0.05);The incision length,blood loss,analgesic time,length of hospital stay of test group was better than that of control group,the difference was statistically significant(t =22.539,t =22.787,t =2.792,t =5.968,all P 0.05).The 1 year,2 year survival rate,recurrence rate of two groups were not significant different(x~2= 0.546,x~2= 1.094,x~2=0.477,x~2=0.944,all P 0.05).After surgery,the FEV,(65.31 ±8.95)%,MV(123.79 ±25.43) L.of test group were higher than the control group(53.79 ±7.20)%,(105.87 ± 18.24)L,the difference was statistically significant(t =6.948,t =3.967,P 0.05).Test PA(225.41 ±49.20) mg/L of test group was higher than the control group(158.53 ±48.27)mg/L,the WBC(12.68±2.75) ×10~9/L of test group was lower than the control group(15.49 ±3.27) × 10~9/L,the Pentraxin 3(3.28 ±0.73) g/L,HE4(104.67 ± 19.24) pmol/L of test group was lower than the control group(5.59 ± 1.30) g/L,(125.76 ±24.21) pmol/L,the difference was statistically significant(t =6.723,t =4.557,t =10.734,t =4.725,P 0.05).The complication rate 35.42%(17/48) of test group was lower than the control group 8.33%(4/48)(x~2=10.301,P 0.05).Conclusion Thoracoscope surgery in patients with lung cancer in the near future curative effect is positive,it can reduce serum Pentraxin 3,HE4 levels.
【CateGory Index】: R734.2
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